IgG4-associated hypophysitis coexisting with MALT lymphoma and gangliocytoma: first case report and literature review

Dongbo Zou; Li Jiang; Tao Yang; Jingmin Cheng; Yuan Ma

doi:10.3389/fneur.2023.1253821

IgG4-associated hypophysitis coexisting with MALT lymphoma and gangliocytoma: first case report and literature review

Front Neurol. 2023 Nov 9:14:1253821. doi: 10.3389/fneur.2023.1253821. eCollection 2023.

Authors

Dongbo Zou¹, Li Jiang², Tao Yang¹, Jingmin Cheng^#¹, Yuan Ma^#¹

Affiliations

¹ Department of Neurosurgery, General Hospital of Western Theater Command, Chengdu, China.
² Department of Rheumatology and Immunology, The Second People's Hospital of Chengdu, Chengdu, China.

^# Contributed equally.

Abstract

IgG4-related or IgG4-associated hypophysitis is a rare disease characterized by the infiltration of IgG4-positive plasma cells into pituitary gland tissue. Gangliocytomas in the sellar region are also extremely rare and are associated with pituitary adenomas in the majority of cases. Sellar mucosa-associated lymphoid tissue (MALT) lymphoma is an exceedingly rare condition. In this study, we present a case of IgG4-associated hypophysitis coexisting with MALT lymphoma and gangliocytoma. However, to elucidate the potential pathophysiological relationship, it is imperative to gather additional cases of IgG4-related hypophysitis accompanied by MALT lymphoma and gangliocytoma.

Keywords: IgG4-related hypophysitis; MALT lymphoma; gangliocytomas; headaches; sellar region; vision loss.

Publication types

Case Reports

Grants and funding

The authors declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Hospital Foundation of General Hospital of Western Theater Command (2021-XZYG-A13 to YM).