From intestinal metaplasia to gastric cancer: Witnessing the rise of evil over time and space

Cheng Zhang; Xi Jiao; Lin Shen

doi:10.1016/j.ccell.2023.10.005

From intestinal metaplasia to gastric cancer: Witnessing the rise of evil over time and space

Cancer Cell. 2023 Dec 11;41(12):2011-2013. doi: 10.1016/j.ccell.2023.10.005. Epub 2023 Oct 26.

Authors

Cheng Zhang¹, Xi Jiao², Lin Shen³

Affiliations

¹ State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
² Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
³ State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China. Electronic address: shenlin@bjmu.edu.cn.

PMID: 37890491
DOI: 10.1016/j.ccell.2023.10.005

Abstract

Intestinal metaplasia (IM) is a precancerous lesion associated with increased gastric cancer (GC) risk. However, the molecular characteristics and heterogeneity distinguishing the two stages remain unclear. Huang et al. provide a spatiotemporal insight into the transition from IM to GC, offering the potential for tailored precision prevention strategies for GC.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Gastric Mucosa / pathology
Humans
Metaplasia
Precancerous Conditions* / pathology
Risk
Stomach Neoplasms*