Cerebral venous sinus thrombosis and thrombocytopenia due to heparin-independent anti-PF4 antibodies after adenovirus infection

Günalp Uzun; Jan Zlamal; Karina Althaus; Andrea Bevot; Florian Hennersdorf; Nina Wolska; Anna Jock; Jan Kern; Vanya Icheva; Sven Poli; Ulrike Ernemann; Andreas Neu; Tamam Bakchoul

doi:10.3324/haematol.2023.284127

Cerebral venous sinus thrombosis and thrombocytopenia due to heparin-independent anti-PF4 antibodies after adenovirus infection

Haematologica. 2024 Jun 1;109(6):2010-2015. doi: 10.3324/haematol.2023.284127.

Authors

Günalp Uzun¹, Jan Zlamal¹, Karina Althaus¹, Andrea Bevot², Florian Hennersdorf³, Nina Wolska⁴, Anna Jock⁵, Jan Kern⁵, Vanya Icheva⁵, Sven Poli⁶, Ulrike Ernemann³, Andreas Neu⁷, Tamam Bakchoul¹

Affiliations

¹ Institute for Clinical and Experimental Transfusion Medicine, University Hospital of Tuebingen, Tuebingen, Germany; Center for Clinical Transfusion Medicine, Tuebingen.
² Department of Neuropediatrics and Developmental Medicine, University Children's Hospital, University of Tuebingen, Tuebingen.
³ Department of Diagnostic and Interventional Neuroradiology, University Hospital Tuebingen.
⁴ Institute for Clinical and Experimental Transfusion Medicine, University Hospital of Tuebingen, Tuebingen.
⁵ Department of Pediatric Cardiology, Pulmonology and Intensive Care Medicine, University Children's Hospital, University of Tuebingen, Tuebingen.
⁶ Department of Neurology and Stroke, University Hospital of Tuebingen, Tuebingen, Germany; Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Tuebingen.
⁷ Department of Pediatric Endocrinology and Diabetes, University Children's Hospital, University of Tuebingen, Tuebingen.

No abstract available

Publication types

Case Reports
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adenoviridae Infections / complications
Adenoviridae Infections / immunology
Autoantibodies / blood
Autoantibodies / immunology
Female
Heparin* / adverse effects
Humans
Male
Platelet Factor 4* / immunology
Sinus Thrombosis, Intracranial* / diagnosis
Sinus Thrombosis, Intracranial* / etiology
Thrombocytopenia* / diagnosis
Thrombocytopenia* / etiology
Thrombocytopenia* / immunology

Substances

Platelet Factor 4
Heparin
Autoantibodies
PF4 protein, human

Grants and funding

Funding: This work was supported by grants from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) and from the Herzstiftung to TB (BA5158/4 and TSG-Study). GU (CS 3014-0-0) and JZ (CS 3015-0-0) take part in the MINT-Clinician Scientist Program of the Medical Faculty Tübingen, funded by DFG (493665037).