Association of Cytomegalovirus (CMV) DNAemia With Long-Term Mortality in a Randomized Trial of Preemptive Therapy and Antiviral Prophylaxis for Prevention of CMV Disease in High-Risk Donor Seropositive, Recipient Seronegative Liver Transplant Recipients

Clin Infect Dis. 2024 Mar 20;78(3):719-722. doi: 10.1093/cid/ciad643.

Abstract

In a post-hoc analysis of the association of CMV DNAemia with long-term mortality in a randomized trial of CMV preemptive therapy vs. antiviral prophylaxis in D+R- liver transplant recipients, post-intervention CMV DNAemia was associated with increased mortality after adjusting for study arm.

Keywords: antiviral therapy; cytomegalovirus; immunocompromised host; liver transplant; viral infections.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antiviral Agents / therapeutic use
  • Cytomegalovirus / genetics
  • Cytomegalovirus Infections* / drug therapy
  • Humans
  • Liver Transplantation*
  • Randomized Controlled Trials as Topic
  • Tissue Donors
  • Transplant Recipients

Substances

  • Antiviral Agents