A novel APA-based prognostic signature may predict the prognosis of lung adenocarcinoma in an East Asian population

Wendi Zhang; Yang Hu; Min Qian; Liping Mao; Yanqiong Yuan; Huiwen Xu; Yiran Liu; Anni Qiu; Yan Zhou; Yang Dong; Yutong Wu; Qiong Chen; Xiaobo Tao; Tian Tian; Lei Zhang; Jiahua Cui; Minjie Chu

doi:10.1016/j.isci.2023.108068

A novel APA-based prognostic signature may predict the prognosis of lung adenocarcinoma in an East Asian population

iScience. 2023 Sep 28;26(11):108068. doi: 10.1016/j.isci.2023.108068. eCollection 2023 Nov 17.

Authors

Wendi Zhang¹, Yang Hu¹, Min Qian¹, Liping Mao², Yanqiong Yuan¹, Huiwen Xu¹, Yiran Liu¹, Anni Qiu¹, Yan Zhou¹, Yang Dong¹, Yutong Wu¹, Qiong Chen¹, Xiaobo Tao¹, Tian Tian¹, Lei Zhang¹, Jiahua Cui¹, Minjie Chu¹

Affiliations

¹ Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China.
² Department of Oncology, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Nantong, Jiangsu, China.

Abstract

The role of alternative polyadenylation (APA) in tumor development is becoming increasingly evident, but the impact of APA events on the prognosis of LUAD patients is unclear. Therefore, in the present study, we aimed to analyze specific APA events in LUAD to identify novel prognostic biomarkers for LUAD. We first identified prognostic candidate genes for LUAD associated with APA events and validated them in both the East Asian and the USA cohorts, finding that five genes (DCUN1D5, PSMC4, TFAM, THRA, and TMEM100) were of prognostic significance in both populations. Based on this, an APA-based prognostic signature was constructed for the East Asian population. The predictive accuracy of the prognostic signature was further evaluated by the time-dependent ROC, with 1-, 2-, and 3-year AUCs of 0.86, 0.81, and 0.71, respectively. This study may provide new markers for individualized diagnosis and prognostic assessment of LUAD and potential targets for precision treatment.

Keywords: Biochemistry; Medical science; Physiology.