Cellular rejuvenation to combat HIV-1-related neurocognitive impairment

Philipp N Ostermann; Teresa H Evering

doi:10.1016/j.tim.2023.09.011

Cellular rejuvenation to combat HIV-1-related neurocognitive impairment

Trends Microbiol. 2024 Jan;32(1):13-16. doi: 10.1016/j.tim.2023.09.011. Epub 2023 Oct 14.

Authors

Philipp N Ostermann¹, Teresa H Evering²

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, 10065 New York, NY, USA. Electronic address: pno4001@med.cornell.edu.
² Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, 10065 New York, NY, USA.

PMID: 37845134
PMCID: PMC10843288 (available on 2025-01-01)
DOI: 10.1016/j.tim.2023.09.011

Abstract

HIV-1-related neurocognitive impairment affects a significant proportion of people living with HIV, and accelerated brain aging has been implicated in its pathogenesis. This forum explores the application of cellular rejuvenation strategies to target molecular mechanisms of brain aging, promote neuronal health, and combat cognitive decline.

Keywords: HIV; accelerated aging; cellular rejuvenation; neurocognitive decline; neurodegenerative disease; senescence.

MeSH terms

Aging / pathology
Aging / psychology
Brain
HIV Infections* / complications
HIV Infections* / therapy
HIV-1*
Humans
Rejuvenation

Abstract

MeSH terms

Grants and funding