Priorities and Progress in Diagnostic Research by the Antibacterial Resistance Leadership Group

Kimberly E Hanson; Ritu Banerjee; Sarah B Doernberg; Scott R Evans; Lauren Komarow; Michael J Satlin; Nyssa Schwager; Patricia J Simner; L Gayani Tillekeratne; Robin Patel; Antibacterial Resistance Leadership Group

doi:10.1093/cid/ciad541

Priorities and Progress in Diagnostic Research by the Antibacterial Resistance Leadership Group

Clin Infect Dis. 2023 Oct 16;77(Suppl 4):S314-S320. doi: 10.1093/cid/ciad541.

Authors

Collaborators

Antibacterial Resistance Leadership Group:
Ephraim Tsalik, Erin Abbenante, Keri Baum, Maria Souli, Elizabeth Mocka, Deborah Hopkins, Abhigya Giri, Lijuan Zeng, Kerryl Greenwood-Quaintance, Andrew Dodd, Grant Booth, Yixuan Li, Jason Waller, Praneeta Raza, Zoe Sund, Cathy Wickward, Lijuan Zeng, Weixiao Dai, Toshimitsu Hamasaki, Varduhi Ghazaryan, Erica Raterman, Tamika Samuel, Marina Lee

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, University of Utah, Salt Lake City, Utah, USA.
² Division of Clinical Microbiology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
³ Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
⁴ Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
⁵ Department of Biostatistics, George Washington University, Washington, DC, USA.
⁶ George Washington University Biostatistics Center, Rockville, Maryland, USA.
⁷ Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
⁸ Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.
⁹ Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
¹⁰ Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
¹¹ Duke Global Health Institute, Duke University, Durham, North Carolina, USA.
¹² Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
¹³ Division of Public Health, Infectious Diseases, and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Abstract

The advancement of infectious disease diagnostics, along with studies devoted to infections caused by gram-negative and gram-positive bacteria, is a top scientific priority of the Antibacterial Resistance Leadership Group (ARLG). Diagnostic tests for infectious diseases are rapidly evolving and improving. However, the availability of rapid tests designed to determine antibacterial resistance or susceptibility directly in clinical specimens remains limited, especially for gram-negative organisms. Additionally, the clinical impact of many new tests, including an understanding of how best to use them to inform optimal antibiotic prescribing, remains to be defined. This review summarizes the recent work of the ARLG toward addressing these unmet needs in the diagnostics field and describes future directions for clinical research aimed at curbing the threat of antibiotic-resistant bacterial infections.

Keywords: antibacterial resistance; bacterial infections; diagnostics.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Drug Resistance, Bacterial
Gram-Negative Bacteria
Gram-Negative Bacterial Infections* / drug therapy
Gram-Positive Bacteria
Humans
Leadership*
Microbial Sensitivity Tests

Substances

Anti-Bacterial Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding