How to improve the production of peptidyl compounds in filamentous fungi

Maiko Umemura; Koichi Tamano

doi:10.3389/ffunb.2022.1085624

How to improve the production of peptidyl compounds in filamentous fungi

Front Fungal Biol. 2022 Dec 22:3:1085624. doi: 10.3389/ffunb.2022.1085624. eCollection 2022.

Authors

Maiko Umemura¹, Koichi Tamano^{2

3}

Affiliations

¹ Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
² Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Sapporo, Japan.
³ Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL), National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan.

Abstract

Peptidyl compounds produced by filamentous fungi, which are nonribosomal peptides (NRPs) and ribosomally synthesized and post-translationally modified peptides (RiPPs), are rich sources of bioactive compounds with a wide variety of structures. Some of these peptidyl compounds are useful as pharmaceuticals and pesticides. However, for industrial use, their low production often becomes an obstacle, and various approaches have been challenged to overcome this weakness. In this article, we summarize the successful attempts to increase the production of NRPs and RiPPs in filamentous fungi and present our perspectives on how to improve it further.

Keywords: cyclic peptide; heterologous expression; nonribosomal peptide (NRP); ribosomally synthesized and post-translationally modified peptide (RiPP); secondary metabolite.