A Patient with Addison Disease (Primary Adrenal Insufficiency) Presenting for Surgical Extraction of Third Molars

Sahar Mirfarsi; Dalia Seleem; Airani Sathananthan

doi:10.1016/j.cden.2023.05.006

A Patient with Addison Disease (Primary Adrenal Insufficiency) Presenting for Surgical Extraction of Third Molars

Dent Clin North Am. 2023 Oct;67(4):585-588. doi: 10.1016/j.cden.2023.05.006. Epub 2023 Jul 3.

Authors

Sahar Mirfarsi¹, Dalia Seleem², Airani Sathananthan³

Affiliations

¹ Western University of Health Sciences, College of Dental Medicine, 309 East Second Street, Pomona, CA 91766-1854, USA. Electronic address: sahar.mirfarsi@westernu.edu.
² Western University of Health Sciences, College of Dental Medicine, 309 East Second Street, Pomona, CA 91766-1854, USA.
³ Western University of Health Sciences, College of Osteopathic Medicine of the Pacific, Department of Internal Medicine, 309 East Second Street, Pomona, CA 91766-1854, USA.

PMID: 37714600
DOI: 10.1016/j.cden.2023.05.006

Abstract

The local prevalence of primary adrenal insufficiency (PAI) depends on various factors such as genetics, environment, and timely disease diagnosis. PAI is uncommon, and the prevalence is reported to be 2 per 10,000 population. PAI is commonly caused by an autoimmune process that destroys the adrenal gland, resulting in the loss of glucocorticoid and mineralocorticoid secretion from the adrenal cortex. The lack of cortisol results in impaired glucose/fat/protein metabolism, hypotension, increased adrenocorticotropic hormone secretion, impaired fluid excretion, and hyperpigmentation. PAI has a female predominance and is commonly seen in ages 20 to 50 years but can occur at any age.

Keywords: Addison disease; Endocrine disease; Glucocorticoids; Oral health care providers; Primary adrenal insufficiency.

Publication types

Review

MeSH terms

Addison Disease* / complications
Addison Disease* / diagnosis
Female
Humans
Male
Molar, Third*