Melodic maestros: Unraveling the role of miRNAs in the diagnosis, progression, and drug resistance of malignant pleural mesothelioma

Mai A Abd-Elmawla; Sherif S Abdel Mageed; Tohada M Al-Noshokaty; Mohammed S Elballal; Ahmed I Abulsoud; Shereen Saeid Elshaer; Ahmed A El-Husseiny; Doaa Fathi; Heba M Midan; Nehal I Rizk; Mahmoud A Elrebehy; Ghadir A Sayed; Manar Mohammed El Tabaa; Aya Salman; Osama A Mohammed; Alaa Ashraf; Emad Gamil Khidr; Reem Khaled; Walaa A El-Dakroury; Gouda Kamel Helal; Yasser M Moustafa; Ahmed S Doghish

doi:10.1016/j.prp.2023.154817

Melodic maestros: Unraveling the role of miRNAs in the diagnosis, progression, and drug resistance of malignant pleural mesothelioma

Pathol Res Pract. 2023 Oct:250:154817. doi: 10.1016/j.prp.2023.154817. Epub 2023 Sep 13.

Authors

Mai A Abd-Elmawla¹, Sherif S Abdel Mageed², Tohada M Al-Noshokaty³, Mohammed S Elballal⁴, Ahmed I Abulsoud⁵, Shereen Saeid Elshaer⁶, Ahmed A El-Husseiny⁷, Doaa Fathi³, Heba M Midan⁴, Nehal I Rizk³, Mahmoud A Elrebehy⁴, Ghadir A Sayed⁸, Manar Mohammed El Tabaa⁹, Aya Salman⁸, Osama A Mohammed¹⁰, Alaa Ashraf¹¹, Emad Gamil Khidr¹², Reem Khaled⁴, Walaa A El-Dakroury¹³, Gouda Kamel Helal¹⁴, Yasser M Moustafa¹⁵, Ahmed S Doghish¹⁶

Affiliations

¹ Biochemistry, Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
² Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
³ Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
⁴ Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
⁵ Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt. Electronic address: abulsoudahmed@azhar.edu.eg.
⁶ Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt; Department of Biochemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo 11823, Egypt.
⁷ Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt; Department of Biochemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City 11829, Cairo, Egypt.
⁸ Department of Biochemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City 11829, Cairo, Egypt.
⁹ Pharmacology & Environmental Toxicology, Environmental Studies & Research Institute (ESRI), University of Sadat City, Sadat City 32897, Menoufia, Egypt.
¹⁰ Department of Clinical Pharmacology, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia.
¹¹ Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
¹² Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt.
¹³ Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
¹⁴ Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo 11231, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
¹⁵ Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
¹⁶ Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt. Electronic address: ahmed_doghish@azhar.edu.eg.

PMID: 37713736
DOI: 10.1016/j.prp.2023.154817

Abstract

Malignant pleural mesothelioma (MPM) is a highly lethal form of pleural cancer characterized by a scarcity of effective therapeutic interventions, resulting in unfavorable prognoses for afflicted individuals. Besides, many patients experience substantial consequences from being diagnosed in advanced stages. The available diagnostic, prognostic, and therapeutic options for MPM are restricted in scope. MicroRNAs (miRNAs) are a subset of small, noncoding RNA molecules that exert significant regulatory influence over several cellular processes within cell biology. A wide range of miRNAs have atypical expression patterns in cancer, serving specific functions as either tumor suppressors or oncomiRs. This review aims to collate, epitomize, and analyze the latest scholarly investigations on miRNAs that are believed to be implicated in the dysregulation leading to MPM. miRNAs are also discussed concerning their potential clinical usefulness as diagnostic and prognostic biomarkers for MPM. The future holds promising prospects for enhancing diagnostic, prognostic, and therapeutic modalities for MPM, with miRNAs emerging as a potential trigger for such advancements.

Keywords: Diagnosis; Drug resistance; MPM; Malignant pleural mesothelioma; MiRNA; Prognosis.

Publication types

Review