Thiostrepton induces cell death of acute myeloid leukemia blasts and the associated macrophage population

Isabel Weinhäuser; Diego A Pereira-Martins; Jacobien R Hilberink; Annet Brouwers-Vos; Eduardo M Rego; Gerwin Huls; Jan Jacob Schuringa

doi:10.3324/haematol.2023.283621

Thiostrepton induces cell death of acute myeloid leukemia blasts and the associated macrophage population

Haematologica. 2024 Feb 1;109(2):639-645. doi: 10.3324/haematol.2023.283621.

Authors

Isabel Weinhäuser¹, Diego A Pereira-Martins¹, Jacobien R Hilberink², Annet Brouwers-Vos³, Eduardo M Rego⁴, Gerwin Huls⁵, Jan Jacob Schuringa⁶

Affiliations

¹ Department of Experimental Hematology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands; Department of Internal Medicine, Medical School of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil; Center for Cell Based Therapy, University of São Paulo, Ribeirao Preto, Brazil; Authors contributed equally to this study.
² Department of Experimental Hematology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands; Authors contributed equally to this study.
³ Department of Experimental Hematology, University Medical Centre Groningen, University of Groningen, Groningen.
⁴ Center for Cell Based Therapy, University of São Paulo, Ribeirao Preto.
⁵ Department of Experimental Hematology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands; Lead contact authors.
⁶ Department of Experimental Hematology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands; Lead contact authors. j.j.schuringa@umcg.nl.

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Letter

MeSH terms

Cell Death
Humans
Leukemia, Myeloid, Acute*
Leukocytes
Macrophages
Thiostrepton*

Substances

Thiostrepton

Grants and funding

Funding: This investigation was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, grant no. 2013/08135-2). DAP-M received a fellowship from FAPESP (grant no. 2017/23117-1). IW received a fellowship from FAPESP (grant no. 2015/09228-0). IW and DAP-M were sponsored by the Abel Tasman Talent Program (ATTP) of the Graduate School of Medical Sciences of the University of Groningen/ University Medical Center Groningen (UG/UMCG), the Netherlands.