Low-temperature deposition manufacturing technology: a novel 3D printing method for bone scaffolds

Tianze Sun; Jinzuo Wang; Huagui Huang; Xin Liu; Jing Zhang; Wentao Zhang; Honghua Wang; Zhonghai Li

doi:10.3389/fbioe.2023.1222102

Low-temperature deposition manufacturing technology: a novel 3D printing method for bone scaffolds

Front Bioeng Biotechnol. 2023 Aug 9:11:1222102. doi: 10.3389/fbioe.2023.1222102. eCollection 2023.

Authors

Tianze Sun^{1

2

3}, Jinzuo Wang^{1

2}, Huagui Huang^{1

2}, Xin Liu^{1

2}, Jing Zhang^{1

2}, Wentao Zhang^{1

2}, Honghua Wang³, Zhonghai Li^{1

2}

Affiliations

¹ Department of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, China.
² Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopedic Diseases, Dalian, Liaoning, China.
³ Division of Energy Materials (DNL22), Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

Abstract

The application of three-dimensional printing technology in the medical field has great potential for bone defect repair, especially personalized and biological repair. As a green manufacturing process that does not involve liquefication through heating, low-temperature deposition manufacturing (LDM) is a promising type of rapid prototyping manufacturing and has been widely used to fabricate scaffolds in bone tissue engineering. The scaffolds fabricated by LDM have a multi-scale controllable pore structure and interconnected micropores, which are beneficial for the repair of bone defects. At the same time, different types of cells or bioactive factor can be integrated into three-dimensional structural scaffolds through LDM. Herein, we introduced LDM technology and summarize its applications in bone tissue engineering. We divide the scaffolds into four categories according to the skeleton materials and discuss the performance and limitations of the scaffolds. The ideas presented in this review have prospects in the development and application of LDM scaffolds.

Keywords: bone tissue engineering; low-temperature deposition manufacturing; rapid prototyping manufacturing; scaffold; three-dimensional printing.

Publication types

Review

Grants and funding

This study was supported by the Science and Technology Innovation Foundation of Dalian (2022JJ12SN045) and the Natural Science Foundation of Liaoning Province (2022-MS-322). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.