Interplay of energy metabolism and autophagy

Yuyao Feng; Ying Chen; Xiaoyong Wu; Junye Chen; Qingyan Zhou; Bao Liu; Liqin Zhang; Cong Yi

doi:10.1080/15548627.2023.2247300

Interplay of energy metabolism and autophagy

Autophagy. 2024 Jan;20(1):4-14. doi: 10.1080/15548627.2023.2247300. Epub 2023 Aug 18.

Authors

Yuyao Feng^{1

2

3}, Ying Chen², Xiaoyong Wu², Junye Chen³, Qingyan Zhou², Bao Liu³, Liqin Zhang¹, Cong Yi²

Affiliations

¹ Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, School of Life Sciences, Huzhou University, Huzhou, China.
² Department of Biochemistry, and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
³ Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.

Abstract

Macroautophagy/autophagy, is widely recognized for its crucial role in enabling cell survival and maintaining cellular energy homeostasis during starvation or energy stress. Its regulation is intricately linked to cellular energy status. In this review, covering yeast, mammals, and plants, we aim to provide a comprehensive overview of the understanding of the roles and mechanisms of carbon- or glucose-deprivation related autophagy, showing how cells effectively respond to such challenges for survival. Further investigation is needed to determine the specific degraded substrates by autophagy during glucose or energy deprivation and the diverse roles and mechanisms during varying durations of energy starvation.Abbreviations: ADP: adenosine diphosphate; AMP: adenosine monophosphate; AMPK: AMP-activated protein kinase; ATG: autophagy related; ATP: adenosine triphosphate; ER: endoplasmic reticulum; ESCRT: endosomal sorting complex required for transport; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GD: glucose deprivation; GFP: green fluorescent protein; GTPases: guanosine triphosphatases; HK2: hexokinase 2; K phaffii: Komagataella phaffii; LD: lipid droplet; MAP1LC3/LC3: microtubule-associated protein1 light chain 3; MAPK: mitogen-activated protein kinase; Mec1: mitosis entry checkpoint 1; MTOR: mechanistic target of rapamycin kinase; NAD (+): nicotinamide adenine dinucleotide; OGD: oxygen and glucose deprivation; PAS: phagophore assembly site; PCD: programmed cell death; PtdIns3K: class III phosphatidylinositol 3-kinase; PtdIns3P: phosphatidylinositol-3-phosphate; ROS: reactive oxygen species; S. cerevisiae: Saccharomyces cerevisiae; SIRT1: sirtuin 1; Snf1: sucrose non-fermenting 1; STK11/LKB1: serine/threonine kinase 11; TFEB: transcription factor EB; TORC1: target of rapamycin complex 1; ULK1: unc-51 like kinase 1; Vps27: vacuolar protein sorting 27; Vps4: vacuolar protein sorting 4.

Keywords: AMPK; Snf1; autophagy; carbon starvation; energy metabolism; glucose starvation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

AMP-Activated Protein Kinases / metabolism
Animals
Autophagy*
Energy Metabolism
Glucose
Mammals / metabolism
Mechanistic Target of Rapamycin Complex 1 / metabolism
Protein Serine-Threonine Kinases / metabolism
Saccharomyces cerevisiae* / metabolism

Substances

Protein Serine-Threonine Kinases
Mechanistic Target of Rapamycin Complex 1
AMP-Activated Protein Kinases
Glucose

Grants and funding

The work was supported by the National Key Research and Development Program of China [2021YFC2600104]; the National Science Foundation of China [32122028, 32070739, and 91754107]; and Zhejiang Provincial Natural Science Foundation of China [LR21C070001].