Targeting SARM1 improves autophagic stress-induced axonal neuropathy

Autophagy. 2024 Jan;20(1):29-44. doi: 10.1080/15548627.2023.2244861. Epub 2023 Aug 18.

Abstract

AAV: adeno-associated virus; ATF3: activating transcription factor 3; ATG7: autophagy related 7; AVIL: advillin; cADPR: cyclic ADP ribose; CALC: calcitonin/calcitonin-related polypeptide; CMT: Charcot-Marie-Tooth disease; cKO: conditional knockout; DEG: differentially expressed gene; DRG: dorsal root ganglion; FE-SEM: field emission scanning electron microscopy; IF: immunofluorescence; NCV: nerve conduction velocity; PVALB: parvalbumin; RAG: regeneration-associated gene; ROS: reactive oxygen species; SARM1: sterile alpha and HEAT/Armadillo motif containing 1; SYN1: synapsin I.

Keywords: Activating transcription factor 3; Wallerian degeneration; autophagy; dorsal root ganglion; dystrophic axon; peripheral neuropathy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Armadillo Domain Proteins / genetics
  • Autophagy
  • Axons
  • Calcitonin*
  • Charcot-Marie-Tooth Disease*
  • Cytoskeletal Proteins / genetics
  • Mice
  • Reactive Oxygen Species

Substances

  • Armadillo Domain Proteins
  • Calcitonin
  • Cytoskeletal Proteins
  • Reactive Oxygen Species
  • SARM1 protein, mouse

Grants and funding

The work was supported by the Ministry of Education [2021R1A6C101A425]; National Research Foundation of Korea [2016R1A5A2007009, 2022R1A2C2003414].