National Cancer Institute Collaborative Workshop on Shaping the Landscape of Brain Metastases Research: challenges and recommended priorities

Michelle M Kim; Minesh P Mehta; DeeDee K Smart; Patricia S Steeg; Julie A Hong; Michael G Espey; Pataje G Prasanna; Laura Crandon; Christine Hodgdon; Niki Kozak; Terri S Armstrong; Aki Morikawa; Nicole Willmarth; Kirk Tanner; Adrienne Boire; Melanie Hayden Gephart; Kim A Margolin; Jona Hattangadi-Gluth; Hussein Tawbi; Daniel M Trifiletti; Caroline Chung; Upal Basu-Roy; Robyn Burns; Isabella C Glitza Oliva; Ayal A Aizer; Carey K Anders; Joanne Davis; Manmeet S Ahluwalia; Veronica Chiang; Jing Li; Rupesh Kotecha; Silvia C Formenti; Benjamin M Ellingson; Vinai Gondi; Paul W Sperduto; Jill S Barnholtz-Sloan; Jordi Rodon; Eudocia Q Lee; Mustafa Khasraw; Debra Nana Yeboa; Priscilla K Brastianos; Evanthia Galanis; C Norman Coleman; Mansoor M Ahmed

doi:10.1016/S1470-2045(23)00297-8

National Cancer Institute Collaborative Workshop on Shaping the Landscape of Brain Metastases Research: challenges and recommended priorities

Lancet Oncol. 2023 Aug;24(8):e344-e354. doi: 10.1016/S1470-2045(23)00297-8.

Authors

Michelle M Kim¹, Minesh P Mehta², DeeDee K Smart³, Patricia S Steeg⁴, Julie A Hong⁵, Michael G Espey⁵, Pataje G Prasanna⁵, Laura Crandon⁶, Christine Hodgdon⁷, Niki Kozak⁸, Terri S Armstrong⁹, Aki Morikawa¹⁰, Nicole Willmarth¹¹, Kirk Tanner¹², Adrienne Boire¹³, Melanie Hayden Gephart¹⁴, Kim A Margolin¹⁵, Jona Hattangadi-Gluth¹⁶, Hussein Tawbi¹⁷, Daniel M Trifiletti¹⁸, Caroline Chung¹⁹, Upal Basu-Roy²⁰, Robyn Burns²¹, Isabella C Glitza Oliva¹⁷, Ayal A Aizer²², Carey K Anders²³, Joanne Davis²⁴, Manmeet S Ahluwalia²⁵, Veronica Chiang²⁶, Jing Li¹⁹, Rupesh Kotecha², Silvia C Formenti²⁷, Benjamin M Ellingson²⁸, Vinai Gondi²⁹, Paul W Sperduto³⁰, Jill S Barnholtz-Sloan³¹, Jordi Rodon³², Eudocia Q Lee³³, Mustafa Khasraw³⁴, Debra Nana Yeboa¹⁹, Priscilla K Brastianos³⁵, Evanthia Galanis³⁶, C Norman Coleman⁵, Mansoor M Ahmed³⁷

Affiliations

¹ Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA. Electronic address: michekim@med.umich.edu.
² Department of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, USA.
³ Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
⁴ Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
⁵ Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD, USA.
⁶ Touch4Life, Clarksville, MD, USA.
⁷ GRASP, Baltimore, MD, USA.
⁸ Santa Maria, CA, USA.
⁹ Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
¹⁰ Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
¹¹ American Brain Tumor Association, Chicago, IL, USA.
¹² National Brain Tumor Society, Newton, MA, USA.
¹³ Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
¹⁴ Department of Neurosurgery, Stanford University, Stanford, CA, USA.
¹⁵ St John's Cancer Institute, Santa Monica, CA, USA.
¹⁶ Department of Radiation Oncology, University of California San Diego Health, La Jolla, CA, USA.
¹⁷ Department of Melanoma Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
¹⁸ Department of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL, USA.
¹⁹ Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
²⁰ LUNGevity Foundation, Chicago, IL, USA.
²¹ Melanoma Research Foundation, Washington, DC, USA.
²² Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Boston, MA, USA.
²³ Department of Medicine, Duke University Medical Center, Durham, NC, USA.
²⁴ The Radiosurgery Society, San Jose, CA, USA.
²⁵ Department of Medical Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, USA.
²⁶ Department of Neurosurgery and Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA.
²⁷ Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA.
²⁸ UCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
²⁹ Department of Radiation Oncology, Northwestern Medicine Cancer Center Warrenville and Proton Center, Warrenville, IL, USA.
³⁰ Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA.
³¹ Informatics and Data Science Program, Center for Biomedical Informatics and Information Technology, Trans-Divisional Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
³² Department of Investigational Cancer Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³³ Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
³⁴ Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.
³⁵ Division of Hematology/Oncology and Division of Neuro-Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
³⁶ Department of Oncology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, MN, USA.
³⁷ Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD, USA. Electronic address: ahmedmm@mail.nih.gov.

Abstract

Brain metastases are an increasing global public health concern, even as survival rates improve for patients with metastatic disease. Both metastases and the sequelae of their treatment are key determinants of the inter-related priorities of patient survival, function, and quality of life, mandating a multidimensional approach to clinical care and research. At a virtual National Cancer Institute Workshop in September, 2022, key stakeholders convened to define research priorities to address the crucial areas of unmet need for patients with brain metastases to achieve meaningful advances in patient outcomes. This Policy Review outlines existing knowledge gaps, collaborative opportunities, and specific recommendations regarding consensus priorities and future directions in brain metastases research. Achieving major advances in research will require enhanced coordination between the ongoing efforts of individual organisations and consortia. Importantly, the continual and active engagement of patients and patient advocates will be necessary to ensure that the directionality of all efforts reflects what is most meaningful in the context of patient care.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Biomedical Research*
Brain Neoplasms* / therapy
Consensus
Humans
National Cancer Institute (U.S.)
Quality of Life
United States

Abstract

Publication types

MeSH terms

Grants and funding