Left or right ear? A neuroimaging study using combined taVNS/fMRI to understand the interaction between ear stimulation target and lesion location in chronic stroke

Xiaolong Peng; Brenna Baker-Vogel; Mutaz Sarhan; Edward B Short; Wenzhen Zhu; Hesheng Liu; Steven Kautz; Bashar W Badran

doi:10.1016/j.brs.2023.07.050

Left or right ear? A neuroimaging study using combined taVNS/fMRI to understand the interaction between ear stimulation target and lesion location in chronic stroke

Brain Stimul. 2023 Jul-Aug;16(4):1144-1153. doi: 10.1016/j.brs.2023.07.050. Epub 2023 Jul 28.

Authors

Xiaolong Peng¹, Brenna Baker-Vogel¹, Mutaz Sarhan¹, Edward B Short¹, Wenzhen Zhu², Hesheng Liu³, Steven Kautz⁴, Bashar W Badran⁵

Affiliations

¹ Department of Psychiatry and Behavioral Sciences, Neuro-X Lab, Medical University of South Carolina, Charleston, SC, USA; Deparment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
² Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
³ Deparment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA; Changping Laboratory, Beijing, China.
⁴ Department of Health Sciences and Research, Medical University of South Carolina, Charleston, SC, USA.
⁵ Department of Psychiatry and Behavioral Sciences, Neuro-X Lab, Medical University of South Carolina, Charleston, SC, USA; Deparment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA. Electronic address: badran@musc.edu.

PMID: 37517466
DOI: 10.1016/j.brs.2023.07.050

Abstract

Background: Implanted vagus nerve stimulation (VNS) and transcutaneous auricular VNS (taVNS) have been primarily administered clinically to the unilateral-left vagus nerve. This left-only convention has proved clinically beneficial in brain disorders. However, in stroke survivors, the presence of a lesion in the brain may complicate VNS-mediated signaling, and it is important to understand the laterality effects of VNS in stroke survivors to optimize the intervention.

Objective: To understand whether taVNS delivered to different ear targets relative to the lesion (ipsilesional vs contralesional vs bilateral vs sham) impacts blood oxygenation level dependent (BOLD) signal propagation in stroke survivors.

Methods: We enrolled 20 adults with a prior history of stroke. Each participant underwent a single visit, during which taVNS was delivered concurrently during functional magnetic resonance imaging (fMRI) acquisition. Each participant received three discrete active stimulation conditions (ipsilesional, contralesional, bilateral) and one sham condition in a randomized order. Stimulation-related BOLD signal changes in the active conditions were compared to sham conditions to understand the interaction taVNS and laterality effects.

Results: All active taVNS conditions deactivated the contralesional default mode network related regions compared to sham, however only ipsilesional taVNS enhanced the activations in the ipsilesional visuomotor and secondary visual cortex. Furthermore, we reveal an interaction in task activations between taVNS and cortical visuomotor areas, where ipsilesional taVNS significantly increased ipsilesional visuomotor activity and decreased contralesional visuomotor activity compared to sham.

Conclusion: Laterality of taVNS relative to the lesion is a critical factor in optimizing taVNS in a stroke population, with ipsilesional stimulation providing largest direct brain activation and should be explored further when designing taVNS studies in neurorehabilitation.

Keywords: Stroke; Transcutaneous auricular vagus nerve stimulation; VNS; fMRI; tVNS; taVNS.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adult
Brain / physiology
Humans
Magnetic Resonance Imaging / methods
Neuroimaging
Stroke* / diagnostic imaging
Stroke* / therapy
Transcutaneous Electric Nerve Stimulation* / methods
Vagus Nerve / physiology
Vagus Nerve Stimulation* / methods

Abstract

Publication types

MeSH terms

Grants and funding