In this paper, we experimentally demonstrated a 2-km high-speed optical interconnection with pulse-shaped pre-equalized four-level pulse amplitude modulation (PAM-4) signal generated by a 3-bit digital-to-analog converter (DAC) with the aid of in-band quantization noise suppression techniques under different oversampling ratios (OSRs) to reduce the influence of quantization noise. The simulation results show that the quantization noise suppression capability of high computational complexity digital resolution enhancer (DRE) is sensitive to taps number of the estimated channel and match filter (MF) response when OSR is sufficient, which will lead to further significant computational complexity increase. To better accommodate this issue, channel response-dependent noise shaping (CRD-NS) which also takes channel response into consideration when optimizing quantization noise distribution is proposed to suppress the in-band quantization noise instead of DRE. Experimental results show that about 2 dB receiver sensitivity improvement can be achieved at the hard-decision forward error correction (HD-FEC) threshold for 110 Gb/s pre-equalized PAM-4 signal generated by 3-bit DAC when the traditional NS technique is replaced by the CRD-NS technique. Compared to the high computational complexity DRE technique, in which channel response is also considered, negligible receiver sensitivity penalty is observed for 110 Gb/s PAM-4 signal, when the CRD-NS technique is utilized. Considering both the system cost and bit error ratio (BER) performance, the generation of high-speed PAM signal with 3-bit DAC enabled by the CRD-NS technique is regarded as a promising scheme for optical interconnection.