Microalgae, Seaweeds and Aquatic Bacteria, Archaea, and Yeasts: Sources of Carotenoids with Potential Antioxidant and Anti-Inflammatory Health-Promoting Actions in the Sustainability Era

Mar Drugs. 2023 Jun 1;21(6):340. doi: 10.3390/md21060340.

Abstract

Carotenoids are a large group of health-promoting compounds used in many industrial sectors, such as foods, feeds, pharmaceuticals, cosmetics, nutraceuticals, and colorants. Considering the global population growth and environmental challenges, it is essential to find new sustainable sources of carotenoids beyond those obtained from agriculture. This review focuses on the potential use of marine archaea, bacteria, algae, and yeast as biological factories of carotenoids. A wide variety of carotenoids, including novel ones, were identified in these organisms. The role of carotenoids in marine organisms and their potential health-promoting actions have also been discussed. Marine organisms have a great capacity to synthesize a wide variety of carotenoids, which can be obtained in a renewable manner without depleting natural resources. Thus, it is concluded that they represent a key sustainable source of carotenoids that could help Europe achieve its Green Deal and Recovery Plan. Additionally, the lack of standards, clinical studies, and toxicity analysis reduces the use of marine organisms as sources of traditional and novel carotenoids. Therefore, further research on the processing of marine organisms, the biosynthetic pathways, extraction procedures, and examination of their content is needed to increase carotenoid productivity, document their safety, and decrease costs for their industrial implementation.

Keywords: agro-food; antioxidant activity; bioactives; blue economy; cosmetics; functional foods; human health; marine organisms; marine resources; natural pigments.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / metabolism
  • Anti-Inflammatory Agents / pharmacology
  • Antioxidants / metabolism
  • Antioxidants / pharmacology
  • Aquatic Organisms
  • Archaea
  • Bacteria
  • Carotenoids / metabolism
  • Carotenoids / pharmacology
  • Microalgae* / metabolism
  • Seaweed*
  • Yeasts

Substances

  • Carotenoids
  • Antioxidants
  • Anti-Inflammatory Agents

Grants and funding

C.R. and J.M. contributions were financed by The Research Council of Norway (326803 SUSKELPFOOD; 319577 SAFER-IMTA, 294946 SBP-N) and Møreforsking AS. P.M.-B. and A.J.M.-M. acknowledge Grant PID2019-110438RB-C21 (NEWCARFOODS), funded by MCIN/AEI/10.13039/501100011033. P.G.-V., A.L.-V. and R.L. acknowledge FITORIBOPEP-P20_00728. PROY. I + D + I JUNTA ANDALUCIA 2020, AGL2019-110438RB-C22-AEI/FEDER, Fertinagro Biotech Foundation (Cátedra Fertinagro Biotech de la Universidad de Huelva). P.M.-B. was supported by a posdoc fellowship from Consejería de Transformación Económica, Industria, Conocimiento y Universidades de la Junta de Andalucía (PAIDI 2020). P.G.-V. and A.L.-V. wants to thank also Next Generation European Funds and the Ministry of Universities of Spain for funding the Recualificación del Profesorado Universitario system. V.S. and E.V. acknowledge CSIC I + D 2018 250 UdelaR, ANII POS NAC 2014 1 102321, and Ph.D. grant CAP UdelaR 2017–2019.