Visible-Light-Induced Aminochlorination of Alkenes

Org Lett. 2023 Jun 23;25(24):4581-4585. doi: 10.1021/acs.orglett.3c01645. Epub 2023 Jun 8.

Abstract

Photoinduced N-internal vicinal aminochlorination of styrene-type terminal alkenes was developed. The reaction proceeded without any catalyst, and the use of N-chloro(fluorenone imine) as both a photoactivatable aminating agent and a chlorinating agent was essential. The imine moiety, introduced at the internal position of the alkenes, could be hydrolyzed under mild conditions to provide versatile β-chlorinated primary amines, the synthetic utility of which was demonstrated by several transformations.

MeSH terms

  • Alkenes*
  • Amines*
  • Catalysis
  • Hydrocarbons, Chlorinated / chemistry
  • Light
  • Styrene

Substances

  • Alkenes
  • Amines
  • Styrene
  • Hydrocarbons, Chlorinated