Stratification of Nontuberculous Mycobacterial Disease Risk in Type 2 Diabetes Based on Metformin Use: a Population-Based Cohort Study in South Korea

Hyeon Hwa Kim; Seonok Kim; Mi Ae Kim; Chang Hee Jung; Yong Pil Chong; Tae Sun Shim; Ye-Jee Kim; Kyung-Wook Jo

doi:10.1128/aac.01675-22

Stratification of Nontuberculous Mycobacterial Disease Risk in Type 2 Diabetes Based on Metformin Use: a Population-Based Cohort Study in South Korea

Antimicrob Agents Chemother. 2023 Jun 15;67(6):e0167522. doi: 10.1128/aac.01675-22. Epub 2023 May 24.

Authors

Hyeon Hwa Kim^#¹, Seonok Kim^#², Mi Ae Kim³, Chang Hee Jung⁴, Yong Pil Chong⁵, Tae Sun Shim¹, Ye-Jee Kim², Kyung-Wook Jo¹

Affiliations

¹ Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
² Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
³ Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea.
⁴ Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
⁵ Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

^# Contributed equally.

Abstract

In a 1:4 case-control matched analysis of data from a nationwide population-based cohort in South Korea, we evaluated whether metformin use mitigates the risk of nontuberculous mycobacterial disease in patients with type 2 diabetes. Multivariable analysis revealed no significant association of metformin use with a diminished risk for incident nontuberculous mycobacterial disease in patients with type 2 diabetes.

Keywords: NTM disease; metformin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cohort Studies
Diabetes Mellitus, Type 2* / drug therapy
Diabetes Mellitus, Type 2* / epidemiology
Humans
Incidence
Lung Diseases*
Metformin* / therapeutic use
Mycobacterium Infections, Nontuberculous* / microbiology
Nontuberculous Mycobacteria
Republic of Korea / epidemiology

Substances

Metformin