Allelic variation within the major APOE CpG island affects its methylation in the brain of targeted replacement mice expressing human APOE

Biochim Biophys Acta Gene Regul Mech. 2023 Sep;1866(3):194942. doi: 10.1016/j.bbagrm.2023.194942. Epub 2023 May 15.

Authors

Johanna Rueter¹, Gerald Rimbach², Patricia Huebbe¹

Affiliations

¹ Institute of Human Nutrition and Food Science, University of Kiel, Hermann-Rodewald-Strasse 6, D-24118 Kiel, Germany.
² Institute of Human Nutrition and Food Science, University of Kiel, Hermann-Rodewald-Strasse 6, D-24118 Kiel, Germany. Electronic address: rimbach@foodsci.uni-kiel.de.

PMID: 37196888
DOI: 10.1016/j.bbagrm.2023.194942

No abstract available

Keywords: Apolipoprotein E; Chromatin immunoprecipitation; DNA methylation; Epigenetics; Methyl-CpG binding protein 2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Animals
Apolipoproteins E / genetics
Brain*
CpG Islands / genetics
DNA Methylation*
Humans
Mice

Substances

Apolipoproteins E