Mitochondrial remodeling in colorectal cancer initiation, progression, metastasis, and therapy: A review

Nourhan M Abdelmaksoud; Ahmed I Abulsoud; Tamer M Abdelghany; Shereen Saeid Elshaer; Sherine Maher Rizk; Mahmoud A Senousy

doi:10.1016/j.prp.2023.154509

Mitochondrial remodeling in colorectal cancer initiation, progression, metastasis, and therapy: A review

Pathol Res Pract. 2023 Jun:246:154509. doi: 10.1016/j.prp.2023.154509. Epub 2023 May 8.

Authors

Nourhan M Abdelmaksoud¹, Ahmed I Abulsoud², Tamer M Abdelghany³, Shereen Saeid Elshaer⁴, Sherine Maher Rizk⁵, Mahmoud A Senousy⁶

Affiliations

¹ Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, 3 Cairo-Belbeis Desert Road, P.O. Box 3020 El Salam, 11785 Cairo, Egypt.
² Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, 3 Cairo-Belbeis Desert Road, P.O. Box 3020 El Salam, 11785 Cairo, Egypt; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11823, Egypt. Electronic address: Abulsoudahmed@azhar.edu.eg.
³ Department of Pharmacology and Toxicology, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11884, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Heliopolis University, 3 Cairo-Belbeis Desert Road, P.O. Box 3020 El Salam, 11785 Cairo, Egypt.
⁴ Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, 3 Cairo-Belbeis Desert Road, P.O. Box 3020 El Salam, 11785 Cairo, Egypt; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo 11823, Egypt.
⁵ Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt. Electronic address: sherine.abdelaziz@cu.edu.eg.
⁶ Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt; Department of Biochemistry, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, Cairo 11786, Egypt.

PMID: 37182313
DOI: 10.1016/j.prp.2023.154509

Abstract

Colorectal cancer (CRC) is a major health concern with multifactorial pathophysiology representing intense therapeutic challenges. It is well known that deregulation of spatiotemporally-controlled signaling pathways and their metabolic reprogramming effects play a pivotal role in the development and progression of CRC. As such, the mitochondrial role in CRC initiation gained a lot of attention recently, as it is considered the powerhouse that regulates the bioenergetics in CRC. In addition, the crosstalk between microRNAs (miRNAs) and mitochondrial dysfunction has become a newfangled passion for deciphering CRC molecular mechanisms. This review sheds light on the relationship between different signaling pathways involved in metabolic reprogramming and their therapeutic targets, alterations in mitochondrial DNA content, mitochondrial biogenesis, and mitophagy, and the role of polymorphisms in mitochondrial genes as well as miRNAs regulating mitochondrial proteins in CRC initiation, progression, metastasis, and resistance to various therapies.

Keywords: Colorectal cancer; Metabolic reprogramming; Mitochondrial coordination; Mitochondrial dysfunction; Mitochondrial resistance.

Publication types

Review

MeSH terms

Colorectal Neoplasms* / pathology
Energy Metabolism
Gene Expression Regulation, Neoplastic
Humans
MicroRNAs* / genetics
Mitochondria / genetics
Signal Transduction

Substances

MicroRNAs