Parental history of dementia and the risk of dementia: A cross-sectional analysis of a global collaborative study

Dae Jong Oh; Jong Bin Bae; Darren M Lipnicki; Ji Won Han; Perminder S Sachdev; Tae Hui Kim; Kyung Phil Kwak; Bong Jo Kim; Shin Gyeom Kim; Jeong Lan Kim; Seok Woo Moon; Joon Hyuk Park; Seung-Ho Ryu; Jong Chul Youn; Dong Young Lee; Dong Woo Lee; Seok Bum Lee; Jung Jae Lee; Jin Hyeong Jhoo; Ingmar Skoog; Jenna Najar; Therese R Sterner; Antonio Guaita; Roberta Vaccaro; Elena Rolandi; Nikolaos Scarmeas; Mary Yannakoulia; Mary H Kosmidis; Steffi G Riedel-Heller; Susanne Roehr; Jacqueline Dominguez; Ma Fe De Guzman; Krizelle Cleo Fowler; Antonio Lobo; Pedro Saz; Raul Lopez-Anton; Kaarin J Anstey; Nicolas Cherbuin; Moyra E Mortby; Henry Brodaty; Julian Trollor; Nicole Kochan; Ki Woong Kim; for Cohort Studies of Memory in an International Consortium (COSMIC)

doi:10.1111/pcn.13561

Parental history of dementia and the risk of dementia: A cross-sectional analysis of a global collaborative study

Psychiatry Clin Neurosci. 2023 Aug;77(8):449-456. doi: 10.1111/pcn.13561. Epub 2023 May 24.

Authors

Dae Jong Oh¹, Jong Bin Bae², Darren M Lipnicki³, Ji Won Han^{2

4}, Perminder S Sachdev^{3

5}, Tae Hui Kim⁶, Kyung Phil Kwak⁷, Bong Jo Kim⁸, Shin Gyeom Kim⁹, Jeong Lan Kim¹⁰, Seok Woo Moon¹¹, Joon Hyuk Park¹², Seung-Ho Ryu¹³, Jong Chul Youn¹⁴, Dong Young Lee^{2

15}, Dong Woo Lee¹⁶, Seok Bum Lee¹⁷, Jung Jae Lee¹⁷, Jin Hyeong Jhoo¹⁸, Ingmar Skoog^{19

20}, Jenna Najar^{19

20}, Therese R Sterner¹⁹, Antonio Guaita²¹, Roberta Vaccaro²¹, Elena Rolandi²¹, Nikolaos Scarmeas^{22

23}, Mary Yannakoulia²⁴, Mary H Kosmidis²⁵, Steffi G Riedel-Heller²⁶, Susanne Roehr^{26

27}, Jacqueline Dominguez^{28

29}, Ma Fe De Guzman²⁹, Krizelle Cleo Fowler²⁹, Antonio Lobo³⁰, Pedro Saz³⁰, Raul Lopez-Anton³¹, Kaarin J Anstey^{32

33

34}, Nicolas Cherbuin³³, Moyra E Mortby^{32

34}, Henry Brodaty³, Julian Trollor^{3

35}, Nicole Kochan³, Ki Woong Kim^{2

4

36}; for Cohort Studies of Memory in an International Consortium (COSMIC)

Affiliations

¹ Workplace Mental Health Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
² Department of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea.
³ Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, New South Wales, Australia.
⁴ Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea.
⁵ Dementia Collaborative Research Centre, University of New South Wales, Sydney, New South Wales, Australia.
⁶ Department of Psychiatry, Yonsei University Wonju Severance Christian Hospital, Wonju, South Korea.
⁷ Department of Psychiatry, Dongguk University Gyeongju Hospital, Gyeongju, South Korea.
⁸ Department of Psychiatry, Gyeongsang National University, School of Medicine, Jinju, South Korea.
⁹ Department of Neuropsychiatry, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea.
¹⁰ Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, South Korea.
¹¹ Department of Psychiatry, School of Medicine, Konkuk University and Konkuk University Chungju Hospital, Chungju, South Korea.
¹² Department of Neuropsychiatry, Jeju National University Hospital, Jeju, South Korea.
¹³ Department of Psychiatry, School of Medicine, Konkuk University and Konkuk University Medical Center, Seoul, South Korea.
¹⁴ Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Yongin, South Korea.
¹⁵ Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.
¹⁶ Department of Neuropsychiatry, Inje University Sanggye Paik Hospital, Seoul, South Korea.
¹⁷ Department of Psychiatry, Dankook University Hospital, Cheonan, South Korea.
¹⁸ Department of Neuropsychiatry, Kangwon National University Hospital, Chuncheon, South Korea.
¹⁹ Department of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP), University of Gothenburg, Mölndal, Sweden.
²⁰ Region Västra Götaland, Sahlgrenska University Hospital Psychiatry, Cognition and Old Age Psychiatry Clinic, Gothenburg, Sweden.
²¹ Golgi Cenci Foundation, Abbiategrasso, Italy.
²² Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
²³ Department of Neurology, Columbia University, New York, New York, USA.
²⁴ Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
²⁵ Lab of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
²⁶ Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany.
²⁷ Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.
²⁸ Institute for Neurosciences, St. Luke's Medical Center, Quezon City, Philippines.
²⁹ Institute for Dementia Care Asia, Quezon City, Philippines.
³⁰ Department of Medicine and Psychiatry, Zaragoza University, Aragon, Spain.
³¹ Departamento de Psicología y Sociología, Universidad de Zaragoza, Aragon, Spain.
³² School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.
³³ Centre for Mental Health Research, Australian National University, Canberra, Canberra, Australia.
³⁴ Neuroscience Australia, Sydney, New South Wales, Australia.
³⁵ Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia.
³⁶ Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences, Seoul, South Korea.

Abstract

Background: Parental history of dementia appears to increase the risk of dementia, but there have been inconsistent results. We aimed to investigate whether the association between parental history of dementia and the risk of dementia are different by dementia subtypes and sex of parent and offspring.

Methods: For this cross-sectional study, we harmonized and pooled data for 17,194 older adults from nine population-based cohorts of eight countries. These studies conducted face-to-face diagnostic interviews, physical and neurological examinations, and neuropsychological assessments to diagnose dementia. We investigated the associations of maternal and paternal history of dementia with the risk of dementia and its subtypes in offspring.

Results: The mean age of the participants was 72.8 ± 7.9 years and 59.2% were female. Parental history of dementia was associated with higher risk of dementia (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.15-1.86) and Alzheimer's disease (AD) (OR = 1.72, 95% CI = 1.31-2.26), but not with the risk of non-AD. This was largely driven by maternal history of dementia, which was associated with the risk of dementia (OR = 1.51, 95% CI = 1.15-1.97) and AD (OR = 1.80, 95% CI = 1.33-2.43) whereas paternal history of dementia was not. These results remained significant when males and females were analyzed separately (OR = 2.14, 95% CI = 1.28-3.55 in males; OR = 1.68, 95% CI = 1.16-2.44 for females).

Conclusions: Maternal history of dementia was associated with the risk of dementia and AD in both males and females. Maternal history of dementia may be a useful marker for identifying individuals at higher risk of AD and stratifying the risk for AD in clinical trials.

Keywords: Alzheimer's disease; dementia; maternal history; parental history; sex.

MeSH terms

Aged
Aged, 80 and over
Alzheimer Disease* / drug therapy
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Parents

Abstract

MeSH terms

Grants and funding