Defining the road map to a UK national lung cancer screening programme

Emma L O'Dowd; Richard W Lee; Ahsan R Akram; Emily C Bartlett; Stephen H Bradley; Kate Brain; Matthew E J Callister; Yan Chen; Anand Devaraj; Sinan R Eccles; John K Field; Jesme Fox; Seamus Grundy; Sam M Janes; Martin Ledson; Melanie MacKean; Anne Mackie; Kieran G McManus; Rachael L Murray; Arjun Nair; Samantha L Quaife; Robert Rintoul; Anne Stevenson; Yvonne Summers; Louise S Wilkinson; Richard Booton; David R Baldwin; Philip Crosbie

doi:10.1016/S1470-2045(23)00104-3

Defining the road map to a UK national lung cancer screening programme

Lancet Oncol. 2023 May;24(5):e207-e218. doi: 10.1016/S1470-2045(23)00104-3.

Authors

Emma L O'Dowd¹, Richard W Lee², Ahsan R Akram³, Emily C Bartlett⁴, Stephen H Bradley⁵, Kate Brain⁶, Matthew E J Callister⁷, Yan Chen⁸, Anand Devaraj⁴, Sinan R Eccles⁹, John K Field¹⁰, Jesme Fox¹¹, Seamus Grundy¹², Sam M Janes¹³, Martin Ledson¹⁴, Melanie MacKean¹⁵, Anne Mackie¹⁶, Kieran G McManus¹⁷, Rachael L Murray¹⁸, Arjun Nair¹⁹, Samantha L Quaife²⁰, Robert Rintoul²¹, Anne Stevenson²², Yvonne Summers²³, Louise S Wilkinson²⁴, Richard Booton²⁵, David R Baldwin¹, Philip Crosbie²⁶

Affiliations

¹ Nottingham University Hospitals NHS Trust, Nottingham, UK.
² Early Diagnosis and Detection Centre, National Institute for Health and Care Research Biomedical Research Centre at the Royal Marsden and Institute of Cancer Research, London, UK; National Heart and Lung Institute, Imperial College London, London, UK. Electronic address: richard.lee@rmh.nhs.uk.
³ Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK; Department of Respiratory Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK.
⁴ Royal Brompton and Harefield Hospitals London and National Heart and Lung Institute, Imperial College London, London, UK.
⁵ School of Medicine, University of Leeds, Leeds, UK.
⁶ Division of Population Medicine, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.
⁷ Leeds Teaching Hospitals NHS Trust, Leeds, UK.
⁸ School of Medicine, University of Nottingham, Nottingham, UK.
⁹ Royal Glamorgan Hospital, Cwm Taf Morgannwg University Health Board, Llantrisant, UK.
¹⁰ Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.
¹¹ Roy Castle Lung Cancer Foundation, Liverpool, UK.
¹² Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK.
¹³ Lungs for Living Research Centre, Department of Respiratory Medicine, University College London, London, UK.
¹⁴ Department of Respiratory Medicine, Liverpool Heart and Chest Hospital, Liverpool, UK.
¹⁵ Edinburgh Cancer Center, Edinburgh, UK.
¹⁶ Public Health England, London, UK.
¹⁷ Department of Thoracic Surgery, Royal Victoria Hospital, Belfast, UK.
¹⁸ Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, UK.
¹⁹ University College London Hospitals NHS Foundation Trust, London, UK.
²⁰ Centre for Prevention, Detection and Diagnosis, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
²¹ Department of Oncology, University of Cambridge, Cambridge, UK.
²² Office for Health Improvement and Disparities, Department of Health and Social Care, London, UK.
²³ The Christie Hospital NHS Trust, Manchester University NHS Foundation Trust, Manchester, UK.
²⁴ Oxford Breast Imaging Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
²⁵ North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
²⁶ North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK; Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

PMID: 37142382
DOI: 10.1016/S1470-2045(23)00104-3

Abstract

Lung cancer screening with low-dose CT was recommended by the UK National Screening Committee (UKNSC) in September, 2022, on the basis of data from trials showing a reduction in lung cancer mortality. These trials provide sufficient evidence to show clinical efficacy, but further work is needed to prove deliverability in preparation for a national roll-out of the first major targeted screening programme. The UK has been world leading in addressing logistical issues with lung cancer screening through clinical trials, implementation pilots, and the National Health Service (NHS) England Targeted Lung Health Check Programme. In this Policy Review, we describe the consensus reached by a multiprofessional group of experts in lung cancer screening on the key requirements and priorities for effective implementation of a programme. We summarise the output from a round-table meeting of clinicians, behavioural scientists, stakeholder organisations, and representatives from NHS England, the UKNSC, and the four UK nations. This Policy Review will be an important tool in the ongoing expansion and evolution of an already successful programme, and provides a summary of UK expert opinion for consideration by those organising and delivering lung cancer screenings in other countries.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Early Detection of Cancer
England
Humans
Lung
Lung Neoplasms* / diagnostic imaging
State Medicine*

Abstract

Publication types

MeSH terms

Grants and funding