Inflammatory markers in children with obstructive sleep apnea syndrome

Yingge Wang; Ying Chen; Wei Lin; Min Huang; Yuanteng Xu; Guohao Chen

doi:10.3389/fped.2023.1134678

Inflammatory markers in children with obstructive sleep apnea syndrome

Front Pediatr. 2023 Apr 11:11:1134678. doi: 10.3389/fped.2023.1134678. eCollection 2023.

Authors

Yingge Wang^{1

2

3}, Ying Chen⁴, Wei Lin^{1

2

3}, Min Huang^{1

2

3}, Yuanteng Xu^{1

2

3}, Guohao Chen^{1

2

3}

Affiliations

¹ Department of Otorhinolaryngology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
² Department of Sleep Medicine Center, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
³ Fujian Institute of Otorhinolaryngology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
⁴ The Second Affiliated Hospital of Xiamen Medical College, Xiaman, China.

Abstract

Objective: To evaluate serum inflammatory markers of YKL-40, Interleukin-6 (IL-6), Interleukin-8(IL-8), Interleukin-10(IL-10), TNF-α(tumor necrosis factor-α), and CRP (C-reactive protein) in children with and without OSAS.

Methods: The ELISA technique has been used to identify the concentration of inflammatory markers such as YKL-40, IL-6, IL-8, IL-10, TNF-α, and CRP in the serum of 83 children with OSAS and 83 children without OSAS.

Results: Serum levels of YKL-40, IL-6, IL-8, and IL-10 were found to be increased in children with OSAS. YKL-40 was found to be positively correlated with IL-6 and IL-8, and negatively correlated with IL-10. At the same time,YKL-40 was also found to be positively correlated with OAHI and LoSpO2% in OSAS group. IL-8 was positively correlated with OAHI whereas IL-10 was positively correlated with LoSpO2.

Conclusion: Children with OSAS are in a systemic inflammatory state. YKL-40 together with IL-8 may act as serum inflammatory markers and provide an indication for the diagnosis of children with OSAS.

Keywords: OSA (Obstructive sleep apnea); YKL-40; inflammatory factors; interleukin; obstructive sleep apnea syndrome.