Objective: To explore the prognostic factors of patients with multiple myeloma (MM) based on nutritional status.
Methods: The Controlling Nutritional Status (CONUT) score and clinical parameters at diagnosis of 203 newly diagnosed MM patients hospitalized in the department of hematology, Wuxi People's Hospital from January 1, 2007 to June 30, 2019 were analyzed retrospectively. The best cut-off value was determined by ROC curve, and the patients were divided into high CONUT group (>6.5 points) and low CONUT group (≤6.5 points); through COX regression multivariate analysis of overall survival (OS) time, CONUT, ISS stage, LDH and treatment response were selected for multiparameter prognostic stratification.
Results: The OS of MM patients in high CONUT group was shorter. The low-risk group (≤2 points) of the multiparameter risk stratification had longer OS time and progression-free survival (PFS) time compared with the high-risk group (>2 points), and it was also effective for different age or karyotype subgroups, new drug groups containing bortezomib and transplant-ineligible subgroup.
Conclusion: The risk stratification of MM patients based on CONUT, ISS stage, LDH and treatment response is worthy of clinical application.
题目: 多发性骨髓瘤患者基于营养状态的长期预后因素分析.
目的: 基于营养状态探讨多发性骨髓瘤（MM）患者的预后影响因素。.
方法: 回顾性分析无锡市人民医院血液科2007年1月1日至2019年6月30日收治的203例初诊MM患者控制营养状况（CONUT）评分及其他临床特征，通过ROC曲线确定最佳截断值，将患者分为高CONUT组（>6.5分）和低CONUT组（≤6.5分）；通过对总生存期（OS）进行COX回归多因素分析，选择CONUT、ISS分期、LDH及治疗反应进行多参数预后分层。.
结果: 高CONUT组MM患者OS较短；多参数风险分层低危组（≤2分）与高危组（>2分）相比具有更长的OS及无进展生存时间（PFS），且在不同年龄或染色体亚组、含硼替佐米的新药组及不适合移植组中仍有意义。.
结论: 基于CONUT、ISS分期、LDH和治疗反应对MM患者进行风险分层具有临床实用性。.
Keywords: CONUT score; multiple myeloma; prognostic factors; risk stratification.