Indications for Fusion With Intradural Spine Tumor Resection in Adults: A Systematic Review and Meta-analysis

World Neurosurg. 2023 Aug:176:21-30. doi: 10.1016/j.wneu.2023.04.041. Epub 2023 Apr 18.

Abstract

Background: The evidence for instrumented fusion in the setting of degenerative, traumatic, or congenital deformity is well established. Data on fusion indications in intradural spinal tumors (IDST) are scarce and reduced to retrospective studies. The objective of this work is to systematically review the published literature since 2015 and analyze the change of practice patterns for stabilization and fusion after intradural tumor resection in adults.

Methods: A systematic literature review was performed via PubMed with the terms: "intradural spinal tumors", "intramedullary spinal tumors", and "intraspinal tumors". The analysis was limited to adult patients with IDST and studies with more than 10 patients. Data on the proportion of patients who underwent instrumentation and had postoperative deformity was pooled in a meta-analysis.

Results: A total of 1073 articles were identified and 47 papers were selected. All the studies were retrospective series and a total of 2473 patients were included. The follow-up ranged from 1 to 96 months, the pooled spinal fixation rate was 6% (95% CI 4.5%-7.6%), the pooled laminoplasty rate was 14.4% (95% CI 5.9%-23%), the pooled rate of postoperative deformity or malalignment in patients with a follow up of at least 6 months was 2.1% (95% CI 1.2%-3%) and just 7 patients were reoperated due to progressive deformity.

Conclusions: Based on existing evidence, the rate of fusion during resection of intradural spinal tumors is low. Prophylactic fixation is often unnecessary and only indicated in unique cases that require extensive bony resection.

Keywords: Fixation; Instrumentation; Intradural spinal tumors; Intramedullary spinal tumors; Postoperative deformity.

Publication types

  • Systematic Review
  • Meta-Analysis
  • Review

MeSH terms

  • Adult
  • Humans
  • Laminectomy
  • Postoperative Complications / surgery
  • Retrospective Studies
  • Spinal Cord Neoplasms* / surgery
  • Spinal Fusion*
  • Spinal Neoplasms* / surgery