Objective: The aim: This study aims to investigate some of the immunological parameters related to Helicobacter pylori patients, including: interleukin (IL-17), cluster of differentiation 4 (CD4), macrophage inhibitory migration factor (MIF), nuclear factor kappa B (NF-kB).
Patients and methods: Materials and methods: The immunological parameters were investigated by using ELISA technology, and compared with the healthy individuals (control).
Results: Results: The level of IL-17A in the serum showed a significant increase (p < 0.05) in the HPP group compared to the control group. The CD4 serum concentration in infected with H. pylori patients was high level (4.23 ± 0.41 ng/ml) with significant increase (p < 0.05) than to healthy individuals (control) (1.93 ± 0.22 ng/ml). Also, there was significant elevation (p < 0.05) in in the level of serum MIF levels in H. pylori patients (75.23 ± 1.88 ng/ml) as compared to the control (65.11 ± 2.25 ng/ml). Serum NF-kB concentration in patients infected with H. pylori was at a high level (8.15 ± 0.58 ng/ml) with a significant elevated (p < 0.05) as compared to control (3.91 ± 0.47 ng/ml). On the other hand, the results proved that there is significant elevation (p < 0.05) in blood NF-kB level in smokers infected with H. pylori (9.43 ± 0.95ng/ml), compared with non-smokers infected with Helicobacter pylori (4.96 ± 1.46 ng/ml).
Conclusion: Conclusions: Both humoral and cellular immune response plays an important role in patients with Helicobacter pylori. The nuclear factor kappa B is considered a risk factor in smoking patients, infected with Helicobacter Pylori can be considered as an early diagnosis of stomach cancer.
Keywords: CD4; Helicobacter pylori; IL-17; MIF; NFkB; immunological parameters.