[Correlation between BRAFV600E mutation and aggressive biological behavior of papillary thyroid carcinoma]

Abstract

The current study analyzed the mutation rate of BRAF^V600E in papillary thyroid carcinoma patients and the correlation between BRAF^V600E mutation and aggressive biological behavior of papillary thyroid carcinoma. A total of 160 patients with papillary thyroid carcinoma who underwent surgical treatment in the Affiliated Cancer Hospital of Zhengzhou University from October 2020 to November 2021 were retrospectively included. All patients underwent BRAF^V600E gene detection. There were 37 males and 123 females, with a mean age of (46.5±11.1) years. The mutation rate of BRAF^V600E was 86.3% (138/160). There was no significant correlation between the mutation of BRAF^V600E and aggressive factors such as age (P=0.917), single focal/multifocal tumor (P=0.673), tumor size (P=0.360), tumor invasion (P=0.150) and regional lymph node metastasis (P=0.406). Therefore, for papillary thyroid cancer, mutations in a single gene like BRAF^V600E fail to determine more active diagnosis and treatment.