Neuronal protein interaction networks in autism spectrum disorder

Lucy K Bicks; Katherine Wade Eyring; Daniel H Geschwind

doi:10.1016/j.xgen.2023.100279

Neuronal protein interaction networks in autism spectrum disorder

Cell Genom. 2023 Mar 8;3(3):100279. doi: 10.1016/j.xgen.2023.100279.

Authors

Lucy K Bicks¹, Katherine Wade Eyring¹, Daniel H Geschwind^{1

2

3

4}

Affiliations

¹ Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
² Department of Psychiatry and Biobehavioral Sciences, Semel Institue, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
³ Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
⁴ Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Abstract

How rare protein-disrupting risk variants implicated in autism spectrum disorders (ASDs) interact or functionally converge is unknown. Pintacuda et al.¹ perform proteomics in induced human neurons and identify more than 1,000 interactions, 90% of which were not previously reported, emphasizing the importance of cell-type- and isoform-specific protein interactions in ASD.

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