Case report: SARS-CoV-2 specific T-cells are associated with myocarditis after COVID-19 vaccination with mRNA-1273

Ulrik Stervbo; Marc Van Bracht; Stathis Philippou; Nina Babel; Timm H Westhoff

doi:10.3389/fmed.2023.1088764

Case report: SARS-CoV-2 specific T-cells are associated with myocarditis after COVID-19 vaccination with mRNA-1273

Front Med (Lausanne). 2023 Mar 3:10:1088764. doi: 10.3389/fmed.2023.1088764. eCollection 2023.

Authors

Ulrik Stervbo¹, Marc Van Bracht², Stathis Philippou³, Nina Babel^{1

4}, Timm H Westhoff⁵

Affiliations

¹ Medical Department I, Center for Translational Medicine and Immune Diagnostics Laboratory, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Herne, Germany.
² Department of Cardiology, Augusta-Krankenanstalt Bochum, Bochum, Germany.
³ Augusta-Krankenanstalt Bochum, Institute for Pathology and Cytology, Bochum, Germany.
⁴ Corporate Member of Freie Universität Berlin, Berlin Center for Advanced Therapies, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
⁵ Medical Department I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Herne, Germany.

Abstract

Vaccination of SARS-CoV-2 with BNT162b2 or mRNA-1273 both have a low incidence of induction of myocarditis. Here we report on utilizing adaptive immune receptor repertoire sequencing (AIRR-Seq) as a way to assess the specificity of tissue infiltrating immune cells.

Keywords: AIRR-Seq; COVID-19; SARS-CoV-2; T cell receptor (TCR); mRNA-1273; myocarditis; vaccination.

Publication types

Case Reports