Non-canonical autophagy in aging and age-related diseases

Anita V Kumar; Joslyn Mills

doi:10.3389/fcell.2023.1137870

Non-canonical autophagy in aging and age-related diseases

Front Cell Dev Biol. 2023 Feb 23:11:1137870. doi: 10.3389/fcell.2023.1137870. eCollection 2023.

Authors

Anita V Kumar¹, Joslyn Mills^{1

2}

Affiliations

¹ Molecular Biology, Cell Biology and Biochemistry Department, Brown University, Providence, RI, United States.
² Wheaton College, Biology Department, Norton, MA, United States.

Abstract

Autophagy, one of the arms of proteostasis, influences aging and age-related diseases. Recently, the discovery of additional roles of autophagy-related proteins in non-canonical degradation and secretion has revealed alternative fates of autophagic cargo. Some of these non-canonical pathways have been linked to neurodegenerative diseases and improving the understanding of this link is crucial for their potential targetability in aging and age-related diseases. This review discusses recent investigations of the involvement of non-canonical autophagy players and pathways in age-related diseases that are now beginning to be discovered. Unraveling these pathways and their relation to classical autophagy could unearth a fascinating new layer of proteostasis regulation during normal aging and in longevity.

Keywords: LANDO; LAP (LC3 associated phagocytosis); aging; neurodegenerative diseasaes; non-canonical autophagy; secretory autophagy.

Publication types

Review