Association of physical activity with loss of knee joint space width over two years: a compositional data analysis in the Osteoarthritis Initiative

D Voinier; T Neogi; L Arbeeva; S Voinier; H Master; L M Thoma; M Brunette; J T Jakiela; D K White

doi:10.1016/j.joca.2022.12.012

Association of physical activity with loss of knee joint space width over two years: a compositional data analysis in the Osteoarthritis Initiative

Osteoarthritis Cartilage. 2023 Aug;31(8):1091-1100. doi: 10.1016/j.joca.2022.12.012. Epub 2023 Feb 21.

Authors

D Voinier¹, T Neogi², L Arbeeva³, S Voinier⁴, H Master⁵, L M Thoma⁶, M Brunette⁷, J T Jakiela⁸, D K White⁹

Affiliations

¹ Department of Physical Therapy, University of Delaware, Newark, DE, USA. Electronic address: mathews@udel.edu.
² Department of Medicine, Section of Rheumatology, Boston University School of Medicine, Boston, MA, USA. Electronic address: tneogi@bu.edu.
³ University of North Carolina at Chapel Hill, Thurston Arthritis Research Center, Chapel Hill, NC, USA. Electronic address: liubov_arbeeva@med.unc.edu.
⁴ Department of Mechanical Engineering, University of Delaware, Newark, DE, USA. Electronic address: voinier@udel.edu.
⁵ Vanderbilt University Medical Center, Vanderbilt Institute for Clinical and Translational Research, Nashville, TN, USA. Electronic address: hiral.master@vumc.org.
⁶ University of North Carolina at Chapel Hill, Division of Physical Therapy, Chapel Hill, NC, USA. Electronic address: louise_thoma@med.unc.edu.
⁷ Evidation Health Inc, San Mateo, CA, USA. Electronic address: meredith.brunette@gmail.com.
⁸ Department of Physical Therapy, University of Delaware, Newark, DE, USA. Electronic address: jtjakiel@udel.edu.
⁹ Department of Physical Therapy, University of Delaware, Newark, DE, USA. Electronic address: dkw@udel.edu.

Abstract

Objective: There is continued debate as to how engaging in physical activity (PA), including moderate-to-vigorous PA (MVPA), light PA (LPA), and sedentary time (SED), affects one's risk for knee osteoarthritis (OA). Traditional regression methods do not account for the codependence of these categories of PA, whereby when one category increases, the others must decrease. Thus, we used compositional data analysis (CoDA) to examine time spent in each category of PA, or PA composition, and its association with loss of knee joint space width (JSW), a common indicator of knee OA progression.

Methods: We performed a secondary analysis of data from a subset of participants in the Osteoarthritis Initiative. These participants had minute-by-minute activity data collected over 7 days at baseline; we then categorized each minute as MVPA, LPA, or SED. Our exposure, PA composition, represented min/day spent in each category. Our outcome, medial JSW loss, was the difference in medial tibiofemoral JSW from baseline to 2 years later. We employed CoDA, using an isometric log-ratio transformation, to examine the association of PA composition with medial JSW loss over 2 years, adjusting for potential confounders.

Results: We included 969 participants (age: 64.5 years, 56% female, body mass index [BMI]: 28.8 kg/m²). Mean PA composition was: MVPA 9.1 min/day, LPA 278 min/day, SED 690 min/day. Per adjusted regression models, higher MVPA was not associated with greater medial JSW loss (β = -0.0005, P = 0.97), nor was LPA (β = 0.06, P = 0.27) or SED (β = -0.06, P = 0.21).

Conclusion: Using CoDA, PA composition was not associated with medial JSW loss over 2 years.

Keywords: Compositional data analysis; Osteoarthritis; Physical activity.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Body Mass Index
Data Analysis
Exercise
Female
Humans
Knee Joint*
Male
Middle Aged
Osteoarthritis, Knee*

Abstract

Publication types

MeSH terms

Grants and funding