Implications and theragnostic potentials of circular RNAs in rheumatic diseases

Alaa Ahmed Abbas; Hadil Adnan Abdulkader; Roberta Giordo; Hossam M Ashour; Gian Luca Erre; Gianfranco Pintus; Hatem Zayed

doi:10.1016/j.ijbiomac.2023.123783

Implications and theragnostic potentials of circular RNAs in rheumatic diseases

Int J Biol Macromol. 2023 Apr 30:235:123783. doi: 10.1016/j.ijbiomac.2023.123783. Epub 2023 Feb 22.

Authors

Alaa Ahmed Abbas¹, Hadil Adnan Abdulkader¹, Roberta Giordo², Hossam M Ashour³, Gian Luca Erre⁴, Gianfranco Pintus⁵, Hatem Zayed⁶

Affiliations

¹ Department of Biomedical Science, College of Health Sciences, Member of QU Health, Qatar University, P.O. Box 2713, Doha, Qatar.
² College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, 505055 Dubai, United Arab Emirates.
³ Department of Integrative Biology, College of Arts and Sciences, University of South Florida, St. Petersburg, FL 33701, USA.
⁴ Rheumatology Unit, Department of Clinical and Experimental Medicine, University Hospital (AOUSS) and University of Sassari, 07100 Sassari, Italy.
⁵ Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43B, 07100 Sassari, Italy; Department of Medical Laboratory Sciences, College of Health Sciences and Sharjah Institute for Medical Research, University of Sharjah, University City Rd, Sharjah 27272, United Arab Emirates. Electronic address: gpintus@uniss.it.
⁶ Department of Biomedical Science, College of Health Sciences, Member of QU Health, Qatar University, P.O. Box 2713, Doha, Qatar. Electronic address: hatem.zayed@qu.edu.qa.

PMID: 36822282
DOI: 10.1016/j.ijbiomac.2023.123783

Abstract

Circular RNAs (circRNAs), a class of non-coding RNAs (ncRNAs), are highly stable and ubiquitous molecules that exhibit tissue-specific expression. Accumulating evidence has shown that aberrant expression of circRNAs can play a role in the pathogenesis of several diseases. Rheumatic diseases are a varied group of autoimmune and inflammatory disorders affecting mainly the musculoskeletal system. Notably, circRNAs, which are essential immune system gene modulators, are strongly linked to the occurrence and progression of autoimmune disorders. Here, we present and discuss the current findings concerning the roles, implications and theragnostic potentials of circRNAs in common rheumatic diseases, including ankylosing spondylitis (AS), osteoarthritis (OA), osteoporosis (OP), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Crohn's disease (CD), and gout. This review aims to provide new insights to support the development of novel diagnostic and therapeutic strategies for these disabling diseases.

Keywords: Circular RNAs; Diagnostic potential; Rheumatic diseases; Therapeutic potential; circRNAs.

Publication types

Review

MeSH terms

Arthritis, Rheumatoid* / metabolism
Autoimmune Diseases*
Humans
RNA, Circular / genetics
Rheumatic Diseases* / genetics
Spondylitis, Ankylosing* / genetics
Spondylitis, Ankylosing* / metabolism

Substances

RNA, Circular