The cost of competency?

Yun-Ruei Kao; Britta Will

doi:10.1016/j.cell.2023.01.010

The cost of competency?

Cell. 2023 Feb 16;186(4):685-687. doi: 10.1016/j.cell.2023.01.010.

Authors

Yun-Ruei Kao¹, Britta Will²

Affiliations

¹ Department of Medicine (Oncology), Albert Einstein College of Medicine / Montefiore Medical Center, Bronx, NY, USA.
² Department of Medicine (Oncology), Albert Einstein College of Medicine / Montefiore Medical Center, Bronx, NY, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: britta.will@einsteinmed.edu.

PMID: 36803600
DOI: 10.1016/j.cell.2023.01.010

Abstract

Curtailed protein translation ensures stemness and multipotency in embryonic and adult tissue-specific stem cells. In this issue of Cell, a study led by Zhao and colleagues uncovered increased susceptibility of hematopoietic stem cells (HSC) to iron-dependent programmed necrotic cell death (ferroptosis) as a consequence of low protein synthesis.

Publication types

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MeSH terms

Cell Proliferation
Ferroptosis
Hematopoietic Stem Cells*
Protein Biosynthesis*