Photophysical, photobiological, and biomolecule-binding properties of new tri-cationic meso-tri(2-thienyl)corroles with Pt(II) and Pd(II) polypyridyl derivatives

Bruna M Rodrigues; Henrique F V Victória; Guilherme Leite; Klaus Krambrock; Otávio A Chaves; Diego F de Oliveira; Rafael de Q Garcia; Leonardo De Boni; Luiz A S Costa; Bernardo A Iglesias

doi:10.1016/j.jinorgbio.2023.112149

Photophysical, photobiological, and biomolecule-binding properties of new tri-cationic meso-tri(2-thienyl)corroles with Pt(II) and Pd(II) polypyridyl derivatives

J Inorg Biochem. 2023 May:242:112149. doi: 10.1016/j.jinorgbio.2023.112149. Epub 2023 Jan 24.

Affiliations

¹ Bioinorganic and Porphyrinoid Material Laboratory, Department of Chemistry, Federal University of Santa Maria, Santa Maria, RS, Brazil.
² Department of Physics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
³ Department of Chemistry, University of Coimbra, Coimbra, Portugal.
⁴ São Carlos Institute of Physics, University of São Paulo, São Carlos, SP, Brazil.
⁵ NEQC - Núcleo de Estudos em Química Computacional, Departament of Chemistry, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil.
⁶ Bioinorganic and Porphyrinoid Material Laboratory, Department of Chemistry, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address: bernardo.iglesias@ufsm.br.

PMID: 36780772
DOI: 10.1016/j.jinorgbio.2023.112149

Abstract

We report the synthesis and characterization of new tri-cationic corrole derivatives, containing Pt(II) or Pd(II) complexes attached at the peripheral position of thienyl moieties. Corrole derivatives were characterized through microanalysis, electrochemical, spectrometry and spectroscopy analysis. Singlet and triplet excited-states are investigated by photophysical/theoretical calculation methods and photobiological parameters were also evaluated spectroscopic techniques (UV-Vis and EPR). Also, the binding capacity of each corrole derivative with nucleic acids (DNA) and human serum albumin (HSA) was determined by UV-Vis, steady-state, and time-resolved fluorescence spectroscopy, combined with molecular docking analysis. Moreover, the new corroles containing peripheral complexes improve their interactions with biomacromolecules, generate reactive oxygen species under light source irradiation studied and has potential for application in photodynamic therapeutic processes.

Keywords: Corroles; Palladium(II) corroles; Photobiology; Platinum(II) corroles; Thienyl-corroles.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Molecular Docking Simulation
Porphyrins* / chemistry
Spectrometry, Fluorescence

Substances

corrole
Porphyrins