[Adipocytes, adipokines and metabolic alterations in pulmonary fibrosis]

K El Husseini; N Poté; M Jaillet; P Mordant; H Mal; J Frija-Masson; R Borie; A Cazes; B Crestani; A Mailleux

doi:10.1016/j.rmr.2023.01.016

[Adipocytes, adipokines and metabolic alterations in pulmonary fibrosis]

Rev Mal Respir. 2023 Mar;40(3):225-229. doi: 10.1016/j.rmr.2023.01.016. Epub 2023 Feb 4.

[Article in French]

Authors

K El Husseini¹, N Poté², M Jaillet³, P Mordant⁴, H Mal⁵, J Frija-Masson⁶, R Borie⁷, A Cazes², B Crestani⁸, A Mailleux³

Affiliations

¹ Service de pneumologie A, Hôpital Bichat, AP-HP ; Inserm Unit 1152, Université de Paris, Paris, France; Inserm Unité 1152 - PHERE, Université de Paris, Paris, France. Electronic address: kinelhu@gmail.com.
² Service d'anatomopathologie, Hôpital Bichat, AP-HP ; Inserm Unité 1152 - PHERE, Université de Paris, Paris, France.
³ Inserm Unité 1152 - PHERE, Université de Paris, Paris, France.
⁴ Service de chirurgie vasculaire et thoracique, Hôpital Bichat, AP-HP, Paris, France.
⁵ Service de pneumologie B, Hôpital Bichat, AP-HP ; Inserm Unité 1152 - PHERE, Université de Paris, Paris, France.
⁶ Service de physiologie-explorations fonctionnelles respiratoires, Hôpital Bichat, AP-HP, Paris, France.
⁷ Service de pneumologie A, Hôpital Bichat, AP-HP ; Inserm Unit 1152, Université de Paris, Paris, France.
⁸ Service de pneumologie A, Hôpital Bichat, AP-HP ; Inserm Unit 1152, Université de Paris, Paris, France; Inserm Unité 1152 - PHERE, Université de Paris, Paris, France.

PMID: 36740493
DOI: 10.1016/j.rmr.2023.01.016

Abstract

Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease characterized by severe remodeling of the lung parenchyma, with an accumulation of activated myofibroblasts and extracellular matrix, along with aberrant cellular differentiation. Within the subpleural fibrous zones, ectopic adipocyte deposits often appear. In addition, alterations in lipid homeostasis have been associated with IPF pathophysiology. In this mini-review, we will discuss the potential involvement of the adipocyte secretome and its paracrine or endocrine-based contribution to the pathophysiology of IPF, via protein or lipid mediators in particular.

Keywords: Adipocytes; Adipokines; Fibrose pulmonaire idiopathique; Idiopathic pulmonary fibrosis; Metabolic syndrome; Syndrome métabolique.

Publication types

Review
English Abstract

MeSH terms

Adipocytes / metabolism
Adipokines*
Humans
Idiopathic Pulmonary Fibrosis*
Lipids
Lung

Substances

Adipokines
Lipids