Genomics of Obsessive-Compulsive Disorder and Related Disorders: What the Clinician Needs to Know

Abstract

A wealth of evidence has shown that genetics plays a major role in susceptibility to obsessive-compulsive disorder (OCD) and all of its related disorders. Several large-scale, collaborative efforts using modern genomic methods are beginning to reveal the genetic architecture of these traits and identify long-sought risk genes. In this article, we summarize current OCD and related disorder genomic knowledge and explain how to communicate this information to patients and their families. The article concludes with a discussion of how genomic discovery in OCD and related disorders can inform our understanding of disease etiology and provide novel targets for therapeutic development.

Keywords: Body dysmorphic disorder; Excoriation disorder; Genetic; Genomic; Hoarding disorder; Obsessive-compulsive disorder; Trichotillomania; Twin.