Effectiveness and safety of anakinra in gouty arthritis: A case series and review of the literature

Sicylle Jeria-Navarro; Alejandro Gomez-Gomez; Hye Sang Park; Enrique Calvo-Aranda; Hector Corominas; Maria Antonia Pou; Cesar Diaz-Torne

doi:10.3389/fmed.2022.1089993

Effectiveness and safety of anakinra in gouty arthritis: A case series and review of the literature

Front Med (Lausanne). 2023 Jan 12:9:1089993. doi: 10.3389/fmed.2022.1089993. eCollection 2022.

Authors

Sicylle Jeria-Navarro¹, Alejandro Gomez-Gomez^{2

3}, Hye Sang Park¹, Enrique Calvo-Aranda^{3

4}, Hector Corominas¹, Maria Antonia Pou⁵, Cesar Diaz-Torne^{1

3}

Affiliations

¹ Rheumatology Department, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain.
² Rheumatology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
³ Crystal-induced Arthritis Study Group, Spanish Society of Rheumatology (GEACSER), Madrid, Spain.
⁴ Rheumatology Department, Hospital Universitario Infanta Leonor, Madrid, Spain.
⁵ EAP Encants, SAP Dreta de Barcelona, ICS, Barcelona, Spain.

Abstract

Background: Gout is the most common type of inflammatory arthritis. Nonsteroidal anti-inflammatory drugs, corticosteroids, and colchicine are the first-line agents, although they are contraindicated in many patients. Blockade of IL-1 with anakinra can be an alternative.

Objective: To present a case series of 10 difficult-to-treat gout patients treated with anakinra and perform a scoping review of the effectiveness and safety of anakinra in gout patients.

Methods: A total of 1,519 citations were screened. The reviewers ran a two-stage screening process by title/abstract and full-text reading. Thirty-eight articles finally met the selection criteria and were included for data extraction and synthesis. Experience in difficult-to treat and complex clinical scenarios, such as active infection, hemodialysis, and transplantation, were specifically described.

Results: The study sample comprised 551 patients, from whom 648 flares were finally analyzed. The mean age was 57.9 years, and 82.9% were men. The clinical presentation was polyarticular in 47.5% and tophaceous in 66.9%. Sixty-five patients with an active infection, 41 transplanted patients and 14 in haemodyalisis treated with anakinra are described. More than half of the patients had >1 associated comorbidity. Anakinra was effective both for flares (94%) and for long-term treatment (91%) and well tolerated. In the case of flares, 34 (6.7%) adverse effects were registered. Adverse events were more prevalent in long-term treatment.

Conclusion: Anakinra was effective and safe for management of gout flares in difficult-to-treat patients. It has been used in multiple complex scenarios, such as active infections, dialysis, transplantation, chronic kidney disease, and polyarticular gout. Anakinra has also proven effective as long-term treatment, although there are more concerns about its safety.

Keywords: IL-1 blockade; IL-1 blocking agents; IL-1 inhibition; anakinra; biological therapies; gout; gout flare; gouty arthritis.