Surveillance in a Neonatal Intensive Care Unit Allowed the Isolation of a Strain of VIM-Producing Pantoea brenneri

Cristina Merla; Irene Mileto; Stefano Gaiarsa; Cristian Achille; Stefano Ghirardello; Marta Corbella; Fausto Baldanti; Patrizia Cambieri

doi:10.3390/antibiotics12010098

Surveillance in a Neonatal Intensive Care Unit Allowed the Isolation of a Strain of VIM-Producing Pantoea brenneri

Antibiotics (Basel). 2023 Jan 6;12(1):98. doi: 10.3390/antibiotics12010098.

Authors

Cristina Merla¹, Irene Mileto^{1

2}, Stefano Gaiarsa¹, Cristian Achille³, Stefano Ghirardello³, Marta Corbella¹, Fausto Baldanti^{1

4}, Patrizia Cambieri¹

Affiliations

¹ UOC Microbiologia e Virologia, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
² Scuola di Specializzazione in Microbiologia e Virologia, Università degli Studi di Pavia, 27100 Pavia, Italy.
³ Neonatologia e Terapia Intensiva Neonatale, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
⁴ Department of Clinical: Surgical, Diagnostic and Pediatric Sciences, Università degli Studi di Pavia, 27100 Pavia, Italy.

Abstract

Here, we describe the isolation of a strain of the genus Pantoea encoding a VIM carbapenemase, the first to our knowledge. The strain, isolated from a rectal swab of a 10-day-old newborn admitted to a neonatal intensive care unit (NICU), was identified through whole-genome sequencing analyses as Pantoea brenneri. The strain harbored the carbapenemases gene bla_VIM-1. The prompt application of contact measures and the isolation of the newborn prevented the dissemination of VIM-producing P. brenneri and of the plasmid carrying the VIM-1 gene to other newborns.

Keywords: Pantoea brenneri; VIM; neonatal intensive care unit; newborn; screening for carbapenemase-resistant Enterobacterales; verona integron β-lactamase.

Publication types

Case Reports

Grants and funding

This research received no external funding.