A microRNA signature for risk-stratification and response prediction to FOLFOX-based adjuvant therapy in stage II and III colorectal cancer

Keisuke Okuno; Raju Kandimalla; Marta Mendiola; Francesc Balaguer; Luis Bujanda; Carlos Fernandez-Martos; Jorge Aparicio; Jaime Feliu; Masanori Tokunaga; Yusuke Kinugasa; Joan Maurel; Ajay Goel

doi:10.1186/s12943-022-01699-2

A microRNA signature for risk-stratification and response prediction to FOLFOX-based adjuvant therapy in stage II and III colorectal cancer

Mol Cancer. 2023 Jan 20;22(1):13. doi: 10.1186/s12943-022-01699-2.

Authors

Keisuke Okuno^#^{1

2}, Raju Kandimalla^#³, Marta Mendiola⁴, Francesc Balaguer⁵, Luis Bujanda⁶, Carlos Fernandez-Martos⁷, Jorge Aparicio⁸, Jaime Feliu⁴, Masanori Tokunaga², Yusuke Kinugasa², Joan Maurel^#⁹, Ajay Goel^{10

11

12}

Affiliations

¹ Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Biomedical Research Center, 1218 S. Fifth Avenue, Suite 2226, Monrovia, CA, 91016, USA.
² Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
³ Center for Gastrointestinal Research; Center for Translational Genomics and Oncology, Baylor Scott & White Research Institute, Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, TX, USA.
⁴ Department of Medical Oncology, La Paz University Hospital (IdiPAZ), CIBERONC, cátedra UAM-AMGEN, Madrid, Spain.
⁵ Department of Gastroenterology, Hospital Clinic de Barcelona, CIBERehd, IDIBAPS, University of Barcelona, Barcelona, Spain.
⁶ Department of Gastroenterology, Instituto Biodonostia, CIBERehd, Universidad del País Vasco (UPV/EHU), San Sebastián, Spain.
⁷ Department of Medical Oncology, Hospital Quiron Salud, Valencia, Spain.
⁸ Department of Medical Oncology, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
⁹ Translational Genomics and Targeted Therapies Group. Medical Oncology, Hospital Clinic of Barcelona, CIBERehd, IDIBAPS, Villarroel 170, 08036, Barcelona, Spain.
¹⁰ Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Biomedical Research Center, 1218 S. Fifth Avenue, Suite 2226, Monrovia, CA, 91016, USA. ajgoel@coh.org.
¹¹ Center for Gastrointestinal Research; Center for Translational Genomics and Oncology, Baylor Scott & White Research Institute, Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, TX, USA. ajgoel@coh.org.
¹² City of Hope Comprehensive Cancer Center, Duarte, CA, USA. ajgoel@coh.org.

^# Contributed equally.

No abstract available

Keywords: Adjuvant chemotherapy; Colorectal cancer; FOLFOX; MicroRNA; Predictive biomarker.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Chemotherapy, Adjuvant
Colorectal Neoplasms* / drug therapy
Colorectal Neoplasms* / genetics
Colorectal Neoplasms* / pathology
Combined Modality Therapy
Fluorouracil / therapeutic use
Humans
MicroRNAs* / genetics
Neoplasm Staging
Prognosis

Substances

MicroRNAs
Fluorouracil