State of art in the chemistry of nucleoside-based Pt(II) complexes

Stefano D'Errico; Andrea Patrizia Falanga; Francesca Greco; Gennaro Piccialli; Giorgia Oliviero; Nicola Borbone

doi:10.1016/j.bioorg.2022.106325

State of art in the chemistry of nucleoside-based Pt(II) complexes

Bioorg Chem. 2023 Feb:131:106325. doi: 10.1016/j.bioorg.2022.106325. Epub 2022 Dec 16.

Authors

Stefano D'Errico¹, Andrea Patrizia Falanga², Francesca Greco³, Gennaro Piccialli⁴, Giorgia Oliviero⁵, Nicola Borbone⁶

Affiliations

¹ Department of Pharmacy, University of Naples Federico II, via Domenico Montesano, 49, 80131 Naples, Italy. Electronic address: stefano.derrico@unina.it.
² Department of Pharmacy, University of Naples Federico II, via Domenico Montesano, 49, 80131 Naples, Italy. Electronic address: andreapatrizia.falanga@unina.it.
³ Department of Pharmacy, University of Naples Federico II, via Domenico Montesano, 49, 80131 Naples, Italy. Electronic address: francesca.greco@unina.it.
⁴ Department of Pharmacy, University of Naples Federico II, via Domenico Montesano, 49, 80131 Naples, Italy. Electronic address: gennaro.piccialli@unina.it.
⁵ Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, via Sergio Pansini, 5, 80131 Naples, Italy. Electronic address: giorgia.oliviero@unina.it.
⁶ Department of Pharmacy, University of Naples Federico II, via Domenico Montesano, 49, 80131 Naples, Italy. Electronic address: nicola.borbone@unina.it.

PMID: 36577221
DOI: 10.1016/j.bioorg.2022.106325

Abstract

After the fortuitous discovery of the anticancer properties of cisplatin, many Pt(II) complexes have been synthesized, to obtain less toxic leads which could overcome the resistance phenomena. Given the importance of nucleosides and nucleotides as antimetabolites, studying their coordinating properties towards Pt(II) ions is challenging for bioorganic and medicinal chemistry. This review aims to describe the results achieved so far in the aforementioned field, paying particular attention to the synthetic aspects, the chemical-physical characterization, and the biological activities of the nucleoside-based Pt(II) complexes.

Keywords: Anticancer drugs; Cancer; Chemotherapy; Cisplatin; DNA; G-Quadruplex; Nucleosides; Pt(II) complexes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antineoplastic Agents* / chemistry
Antineoplastic Agents* / pharmacology
Cisplatin / chemistry
Coordination Complexes* / pharmacology
Nucleosides / pharmacology
Nucleotides
Platinum Compounds* / chemistry
Platinum Compounds* / pharmacology

Substances

Antineoplastic Agents
Cisplatin
Coordination Complexes
Nucleosides
Nucleotides
Platinum Compounds