Genetic Polymorphisms of Cytochromes P450 in Finno-Permic Populations of Russia

Murat Dzhaubermezov; Natalya Ekomasova; Rustam Mustafin; Lilia Gabidullina; Yuliya Galimova; Alfiya Nurgalieva; Yana Valova; Darya Prokofyeva; Elza Khusnutdinova

doi:10.3390/genes13122353

Genetic Polymorphisms of Cytochromes P450 in Finno-Permic Populations of Russia

Genes (Basel). 2022 Dec 13;13(12):2353. doi: 10.3390/genes13122353.

Authors

Affiliations

¹ Federal State Educational Institution of Higher Education, Ufa University of Science and Technology, 450076 Ufa, Russia.
² Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Sciences, 450054 Ufa, Russia.
³ Federal State Educational Institution of Higher Education, Bashkir State Medical University, 450008 Ufa, Russia.
⁴ Federal Institution of Science, Ufa Research Institute of Occupational Health and Human Ecology, 450106 Ufa, Russia.

Abstract

Cytochrome P450 is an enzyme involved in the metabolism of phase 1 xenobiotics, toxins, endogenous hormones, and drugs, including those used in COVID-19 treatment. Cytochrome p450 genes are linked to the pathogenesis of some multifactorial traits and diseases, such as cancer, particularly prostate cancer, colorectal cancer, breast cancer, and cervical cancer. Genotyping was performed on 540 supposedly healthy individuals of 5 Finno-Permic populations from the territories of the European part of the Russian Federation. There was a statistically significant difference between Veps and most of the studied populations in the rs4986774 locus of the CYP2D6 gene; data on the rs3892097 locus of the CYP2D6 gene shows that Izhemsky Komis are different from the Mordovian and Udmurt populations.

Keywords: CYP1A1; CYP2D6; Finno-Permic populations; pharmacogenetic markers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cytochrome P-450 CYP2D6* / genetics
Cytochrome P-450 Enzyme System* / genetics
Cytochrome P-450 Enzyme System* / metabolism
Humans
Polymorphism, Genetic
Russia / ethnology

Substances

Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System

Grants and funding

The work was supported by the State Assignment of the Ministry of Science and Higher Education of the Russian Federation No. 075-03-2021-193/5 and was funded by the Ministry of Science and Education of the Republic of Bashkortostan (agreement no. 1, 2 December 2022) in the part of genotyping; by the Ministry of Science and Higher Education of Russian Federation, grant number 075-15-2021-595, in the part of collection of biological materials. This work has been supported by the grants the Russian Science Foundation, RSF 21-74-00104, in the part of statistical analysis.