Metastatic lymph nodes and prognosis assessed by the number of retrieved lymph nodes in gastric cancer

Hao Wang; Xin Yin; Sheng-Han Lou; Tian-Yi Fang; Bang-Ling Han; Jia-Liang Gao; Yu-Fei Wang; Dao-Xu Zhang; Xi-Bo Wang; Zhan-Fei Lu; Jun-Peng Wu; Jia-Qi Zhang; Yi-Min Wang; Yao Zhang; Ying-Wei Xue

doi:10.4240/wjgs.v14.i11.1230

Metastatic lymph nodes and prognosis assessed by the number of retrieved lymph nodes in gastric cancer

World J Gastrointest Surg. 2022 Nov 27;14(11):1230-1249. doi: 10.4240/wjgs.v14.i11.1230.

Authors

Affiliations

¹ Department of Gastroenterological Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University Cancer Hospital, Harbin 150081, Heilongjiang Province, China.
² Department of Gastroenterological Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University Cancer Hospital, Harbin 150081, Heilongjiang Province, China. xueyingwei@hrbmu.edu.cn.

Abstract

Background: The prognostic value of quantitative assessments of the number of retrieved lymph nodes (RLNs) in gastric cancer (GC) patients needs further study.

Aim: To discuss how to obtain a more accurate count of metastatic lymph nodes (MLNs) based on RLNs in different pT stages and then to evaluate patient prognosis.

Methods: This study retrospectively analyzed patients who underwent GC radical surgery and D2/D2+ LN dissection at the Cancer Hospital of Harbin Medical University from January 2011 to May 2017. Locally weighted smoothing was used to analyze the relationship between RLNs and the number of MLNs. Restricted cubic splines were used to analyze the relationship between RLNs and hazard ratios (HRs), and X-tile was used to determine the optimal cutoff value for RLNs. Patient survival was analyzed with the Kaplan-Meier method and log-rank test. Finally, HRs and 95% confidence intervals were calculated using Cox proportional hazards models to analyze independent risk factors associated with patient outcomes.

Results: A total of 4968 patients were included in the training cohort, and 11154 patients were included in the validation cohort. The smooth curve showed that the number of MLNs increased with an increasing number of RLNs, and a nonlinear relationship between RLNs and HRs was observed. X-tile analysis showed that the optimal number of RLNs for pT1-pT4 stage GC patients was 26, 31, 39, and 45, respectively. A greater number of RLNs can reduce the risk of death in patients with pT1, pT2, and pT4 stage cancers but may not reduce the risk of death in patients with pT3 stage cancer. Multivariate analysis showed that RLNs were an independent risk factor associated with the prognosis of patients with pT1-pT4 stage cancer (P = 0.044, P = 0.037, P = 0.003, P < 0.001).

Conclusion: A greater number of RLNs may not benefit the survival of patients with pT3 stage disease but can benefit the survival of patients with pT1, pT2, and pT4 stage disease. For the pT1, pT2, and pT4 stages, it is recommended to retrieve 26, 31 and 45 LNs, respectively.

Keywords: Gastric cancer; Metastatic lymph nodes; Number of retrieved lymph nodes; Prognosis.