Mechanisms of circular RNA degradation

Longxin Ren; Qingshan Jiang; Liyi Mo; Lijie Tan; Qifei Dong; Lijuan Meng; Nanyang Yang; Guoqing Li

doi:10.1038/s42003-022-04262-3

Mechanisms of circular RNA degradation

Commun Biol. 2022 Dec 9;5(1):1355. doi: 10.1038/s42003-022-04262-3.

Authors

Longxin Ren¹, Qingshan Jiang², Liyi Mo¹, Lijie Tan¹, Qifei Dong¹, Lijuan Meng³, Nanyang Yang⁴, Guoqing Li⁵

Affiliations

¹ The Hengyang Key Laboratory of Cellular Stress Biology, Institute of Cytology and Genetics, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
² Department of Otolaryngology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
³ Department of Ultrasonography, Second Affiliated Hospital, University of South China, Hengyang Hunan, 421001, China.
⁴ The Hengyang Key Laboratory of Cellular Stress Biology, Institute of Cytology and Genetics, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. yangny204@usc.edu.cn.
⁵ The Hengyang Key Laboratory of Cellular Stress Biology, Institute of Cytology and Genetics, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. guoqingli@usc.edu.cn.

Abstract

Circular RNAs (CircRNAs) are a class of noncoding RNAs formed by backsplicing during cotranscriptional and posttranscriptional processes, and they widely exist in various organisms. CircRNAs have multiple biological functions and are associated with the occurrence and development of many diseases. While the biogenesis and biological function of circRNAs have been extensively studied, there are few studies on circRNA degradation and only a few pathways for specific circRNA degradation have been identified. Here we outline basic information about circRNAs, summarize the research on the circRNA degradation mechanisms and discusses where this field might head, hoping to provide some inspiration and guidance for scholars who aim to study the degradation of circRNAs.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

RNA Stability
RNA* / genetics
RNA* / metabolism
RNA, Circular* / genetics

Substances

RNA, Circular
RNA