Effectiveness of Guselkumab Therapy among Patients with Plaque Psoriasis with Baseline IGA Score ≥ 2 in the CorEvitas Psoriasis Registry

April W Armstrong; Timothy Fitzgerald; Robert R McLean; Amanda Teeple; Jonathan P Uy; Mobolaji Olurinde; Katelyn Rowland; Lin Guo; Ying Shan; Kristina Callis Duffin

doi:10.1007/s13555-022-00865-0

Effectiveness of Guselkumab Therapy among Patients with Plaque Psoriasis with Baseline IGA Score ≥ 2 in the CorEvitas Psoriasis Registry

Dermatol Ther (Heidelb). 2023 Feb;13(2):487-504. doi: 10.1007/s13555-022-00865-0. Epub 2022 Dec 9.

Authors

April W Armstrong^{1

2}, Timothy Fitzgerald³, Robert R McLean⁴, Amanda Teeple⁵, Jonathan P Uy⁵, Mobolaji Olurinde⁵, Katelyn Rowland⁵, Lin Guo⁴, Ying Shan⁴, Kristina Callis Duffin⁶

Affiliations

¹ University of Southern California, Los Angeles, CA, USA.
² Harvard Medical School, Boston, MA, USA.
³ Janssen Scientific Affairs, LLC, Horsham, PA, 19044, USA. TFitzg11@its.jnj.com.
⁴ CorEvitas, LLC, Waltham, MA, USA.
⁵ Janssen Scientific Affairs, LLC, Horsham, PA, 19044, USA.
⁶ University of Utah, Salt Lake City, UT, USA.

Abstract

Introduction: In clinical trials, treatment with the interleukin-23 inhibitor guselkumab was associated with significantly improved disease severity and patient-reported outcome measures (PROMs) among patients with moderate-to-severe plaque psoriasis. However, limited information is available regarding the real-world effectiveness of guselkumab among patients with psoriasis of mild, moderate, and severe Investigator's Global Assessment (IGA) severities living in the USA and Canada.

Methods: Patients participating in the CorEvitas Psoriasis Registry between 18 July 2017 and 10 July 2019 who met the following criteria were included: IGA ≥ 2 (mild or greater disease severity), initiated guselkumab at a registry (index) visit, and had a registry follow-up visit after persistent guselkumab treatment for 9 to 12 months. Data were collected for patient demographics, disease characteristics, treatment history, disease activity, and PROMs. At follow-up, outcome measure response rates and mean changes from the index visit were calculated.

Results: Among 130 patients, the mean age was 50.2 years, 39.2% were female, and 56.9% had a body mass index ≥ 30 kg/m². Mean psoriasis duration was 17.5 years and 79.2% of patients had previously received one or more biologic therapy. At the index visit, mean IGA, Psoriasis Area Severity Index (PASI), and Dermatology Life Quality Index (DLQI) scores were 3.0, 9.9, and 8.0, respectively. At follow-up, IGA 0/1 and IGA 0 were achieved by 64.6% and 36.2% of patients, respectively. PASI 75, 90, and 100 were achieved by 61.5%, 46.9%, and 36.9% of patients; 55.4% had maintained or achieved DLQI 0/1. Mean improvements were observed in all evaluated disease activity outcomes and PROMs, with all differing significantly from zero except for the percent of work hours missed due to psoriasis.

Conclusion: In this real-world study, patients with a baseline IGA score ≥ 2 experienced improvements in disease activity and PROMs after 9-12 months of persistent guselkumab treatment.

Keywords: Canada; CorEvitas Psoriasis Registry; Effectiveness; Guselkumab; Psoriasis; Real world; United States.