Evaluation of the impact of nasal colonization with methicillin-resistant Staphylococcus aureus on left ventricular assist device infections

Lauren J Koscal; Holly Meadows; Brian R Raux; Krutika N Mediwala; Erin Weeda; Brian Houston; Deeksha Jandhyala; Jaclyn M Hawn

doi:10.1017/ash.2022.46

Evaluation of the impact of nasal colonization with methicillin-resistant Staphylococcus aureus on left ventricular assist device infections

Antimicrob Steward Healthc Epidemiol. 2022 May 10;2(1):e79. doi: 10.1017/ash.2022.46. eCollection 2022.

Authors

Lauren J Koscal¹, Holly Meadows², Brian R Raux², Krutika N Mediwala², Erin Weeda³, Brian Houston⁴, Deeksha Jandhyala⁵, Jaclyn M Hawn²

Affiliations

¹ Department of Pharmacy, University of Florida Health at Jacksonville, Jacksonville, Florida.
² Department of Pharmacy, Medical University of South Carolina, Charleston, South Carolina.
³ Medical University of South Carolina, College of Pharmacy, Charleston, South Carolina.
⁴ Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.
⁵ Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.

Abstract

In this retrospective cohort study, we evaluated the predictive value of methicillin-resistant Staphylococcus aureus (MRSA) nasal swabs for the development of MRSA infections in patients with left ventricular assist devices. In 106 patients, the MRSA nasal swab had a negative predictive value of 92.9% demonstrating a potential role in antibiotic de-escalation.