Targeting cytokine-induced leukemic stem cell persistence in chronic myeloid leukemia by IKK2-inhibition

Marlena Bütow; Fabio J Testaquadra; Julian Baumeister; Tiago Maié; Nicolas Chatain; Timo Jaquet; Stefan Tillmann; Martina Crysandt; Ivan G Costa; Tim H Brümmendorf; Mirle Schemionek

doi:10.3324/haematol.2022.280922

Targeting cytokine-induced leukemic stem cell persistence in chronic myeloid leukemia by IKK2-inhibition

Haematologica. 2023 Apr 1;108(4):1179-1185. doi: 10.3324/haematol.2022.280922.

Affiliations

¹ Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen.
² Institute for Computational Genomics, Joint Research Center for Computational Biomedicine, RWTH Aachen University, Aachen.
³ Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen. mschemionek@ukaachen.de.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Chronic Disease
Cytokines
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / genetics
Leukemia, Myeloid*
Leukemia, Myeloid, Acute*
Neoplastic Stem Cells
Stem Cells

Substances

Cytokines
IKBKB protein, human

Grants and funding

Funding: This work was supported by the Clinical Research Group entitled “Untangling and Targeting Mechanisms of Myelofibrosis in Myeloproliferative Neoplasms (MPN)” (CRU344) funded by the German Research Foundation (DFG) (SCHE 1938/3-1 [AOBJ 659838]), in the framework of the Research Training Group “Tumor-targeted Drug Delivery" grant 331065168 as well as by the START-Program of the Faculty of Medicine, RWTH Aachen (grant 691706).