The Burden of Dementia Spectrum Disorders and Associated Comorbid and Demographic Features

Behnam Sabayan; Kathryn A Wyman-Chick; Sanaz Sedaghat

doi:10.1016/j.cger.2022.07.001

The Burden of Dementia Spectrum Disorders and Associated Comorbid and Demographic Features

Clin Geriatr Med. 2023 Feb;39(1):1-14. doi: 10.1016/j.cger.2022.07.001. Epub 2022 Oct 21.

Authors

Behnam Sabayan¹, Kathryn A Wyman-Chick², Sanaz Sedaghat³

Affiliations

¹ Department of Neurology, HealthPartners Neuroscience Center, 295 Phalen Boulevard, St Paul, MN 55130, USA; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S Second Street, Suite 300, Minneapolis, MN 55454, USA. Electronic address: bsabayan@umn.edu.
² Department of Neurology, HealthPartners Neuroscience Center, 295 Phalen Boulevard, St Paul, MN 55130, USA.
³ Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S Second Street, Suite 300, Minneapolis, MN 55454, USA.

PMID: 36404023
DOI: 10.1016/j.cger.2022.07.001

Abstract

Dementia spectrum disorders (DSDs) are a major cause of mortality and disability worldwide. DSDs encompass a large group of medical conditions that all ultimately lead to major functional and cognitive decline and disability. Demographic and comorbid conditions that are associated with DSDs have significant prognostic and preventive implications. In this article, we will discuss the global and regional burden of DSDs and cover key demographic and clinical conditions linked with DSDs. In the absence of disease-modifying treatments, the role of primary prevention has become more prominent. Implementation of preventive measures requires an understanding of predisposing and exacerbating factors.

Keywords: Biological sex; Comorbidity; Dementia; Ethnicity; Race.

Publication types

Review

MeSH terms

Cognitive Dysfunction* / epidemiology
Comorbidity
Dementia* / epidemiology
Dementia* / therapy
Demography
Disabled Persons*
Humans