Synthetic biology by controller design

Carlos Barajas; Domitilla Del Vecchio

doi:10.1016/j.copbio.2022.102837

Synthetic biology by controller design

Curr Opin Biotechnol. 2022 Dec:78:102837. doi: 10.1016/j.copbio.2022.102837. Epub 2022 Nov 4.

Authors

Carlos Barajas¹, Domitilla Del Vecchio²

Affiliations

¹ Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: carlobar@mit.edu.
² Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

PMID: 36343564
DOI: 10.1016/j.copbio.2022.102837

Abstract

Natural biological systems display complex regulation and synthetic biomolecular systems have been used to understand their natural counterparts and to parse sophisticated regulations into core design principles. At the same time, the engineering of biomolecular systems has unarguable potential to transform current and to enable new, yet-to-be-imagined, biotechnology applications. In this review, we discuss the progression of control systems design in synthetic biology, from the purpose of understanding the function of naturally occurring regulatory motifs to that of creating genetic circuits whose function is sufficiently robust for biotechnology applications.

Publication types

Review

MeSH terms

Biotechnology
Gene Regulatory Networks
Genetic Engineering*
Synthetic Biology*